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Measurement of myocardial triglyceride content by magnetic resonance spectroscopy in transplant native heart autopsies
© Liu et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Cardiac dysfunction has been associated with excessive myocardial lipolysis in animal models. Measurements of myocardial triglycerides in humans have been performed using proton MR spectroscopy (1H-MRS) [1, 2]. The measured volume is usually selected within the ventricular septum to avoid the contamination from epicardial fat and to eliminate the artifacts from cardiac motion. It is difficult to assess the spatial distribution of the fat deposition in human myocardium by 1H-MRS. Hence, whether the fat content within the septum can be generalized to represent the whole cardiac tissue remains unknown.
We performed 1H-MRS on transplant native heart autopsies to study the distribution of myocardial triglycerides by placing the voxel in different myocardial regions in the samples. The T1 maps were also acquired to examine the cross-sectional relation between myocardial triglyceride content and T1 values.
Fat/Water fractions measured in different regions in the samples.
This study shows the distribution of myocardial triglycerides is heterogeneous in diseased hearts. The conventional procedure of voxel positioning in the septum for MRS is thus likely to only show moderate correlation with overall cardiac steatosis. These results suggest T1 mapping might provide a qualitative index for estimation of relative fat content in combination with the single voxel MRS measurement in the septum.
This article is published under license to BioMed Central Ltd.