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Myocardial T1-Mapping in chronic myocardial infarction: preliminary results of unenhanced and contrast enhanced MR imaging using Gadobutrol
© Bauner et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
At a given field strength tissues present with specific T1-values. Reference values for normal unenhanced myocardium have been established. We hypothesize, that infarcted myocardial tissue can be delineated from normal myocardium by means of T1-maps in unenhanced and contrast-enhanced scans.
Materials and methods
13 patients with chronic myocardial infarction were examined at 1.5 T (Magnetom Avanto, Siemens Healthcare). A modified Look-Locker inversion recovery (MOLLI) sequence (TR/TE 200.7/1.03 msec; TI 100-4000 msec; flip 35°) was performed pre- and 10 min post-contrast (0.15 mmol/kg gadobutrol, Bayer Schering Pharma) at an apical, midmyocardial and basal short axis position. For calculation of T1-values signal intensities of myocardial and infracted tissue were measured at 11 points of time with two blocks of 3 and a third block 5 consecutive image acquisitions. Within each block TI increased by steps of 80 msec.
15 minutes after contrast medium application a single slice IR GRE was employed for imaging of delayed enhancement.
Student's t-test was used for statistical analysis of acquired and calculated data.
MR-measurements of T1-values with the LVC as reference allow for differentiation of infarcted areas from normal myocardium. Further studies are warranted for a normalization of values in order to reduce the dependency on contrast timing, dose and agent.
This article is published under license to BioMed Central Ltd.