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Evaluation of left ventricular wall motion in ischaemic heart disease pre- and post-cardiac surgery using cardiac MR


Evaluation of cardiac mechanics has substantially improved with the advances in non-invasive cardiac MR and echocardiographic techniques.


The purpose of this study was to obtain detailed three-dimensional left ventricular (LV) wall motion in patients with ischaemic heart disease (IHD) before and after coronary artery by-pass graft (CABG) surgery, using navigator gated high temporal resolution tissue phase mapping (TPM). The technique has a higher temporal resolution compared with standard TPM analysis [1, 2] and has allowed visualization of new details of LV motion.


Cardiac gated, phase contrast measurements using respiratory navigator TPM were obtained on 19 patients with ischaemic heart disease (66 ± 7 years old) before and after CABG surgery and in a group of age-matched healthy subjects. LV motion patterns and time-to-peak velocities were obtained for radial, circumferential and longitudinal motion. Ventricular torsion rate and longitudinal strain rate were also derived for each group.


Compared with healthy volunteers, patients with IHD had lower radial velocities, most pronounced at the LV apex, an altered pattern of ventricular rotation and significantly lower longitudinal velocities. Counter-intuitively, there was little change in the time to peak radial velocity between controls and patients with IHD, indicating that time to peak contraction is not a sensitive indicator of contractile dysfunction in the absence of conduction delay. The most pronounced differences in the two groups were peak diastolic longitudinal velocities and peak diastolic longitudinal strain rates. Lower peak systolic and diastolic torsion rates were also noted in patients with IHD. After CABG surgery, improved radial velocities, but reduced circumferential and longitudinal velocities, were observed. No changes in peak torsion or strain rates were recorded after surgery.


Tissue phase mapping allowed three-dimensional assessment of wall motion abnormalities in patients with IHD. It has also been possible to characterize LV remodeling using this method. Longitudinal recoil motion in diastole was the most affected parameter in patients with IHD. The results also suggest that postoperative changes after open cardiac surgery are limiting ventricular rotational and longitudinal motions, despite an increase in ventricular contractility due to revascularization.


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  2. Petersen SE, et al: Myocardial tissue phase mapping with cine phase-contrast MR imaging: regional wall motion analysis in healthy volunteers. Radiology. 2006, 238 (3): 816-826. 10.1148/radiol.2383041992.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Codreanu, I., Pegg, T.J., Holloway, C.J. et al. Evaluation of left ventricular wall motion in ischaemic heart disease pre- and post-cardiac surgery using cardiac MR. J Cardiovasc Magn Reson 12 (Suppl 1), P160 (2010).

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