- Poster presentation
- Open Access
Arrhythmia insensitive inversion recovery preparation (IR-prep) with real-time adaptive inversion delay (TI):phantom validation
© Krishnamurthy et al; licensee BioMed Central Ltd. 2010
- Published: 21 January 2010
- Phantom Study
- Philips Healthcare
- Clinical Reality
- Phantom Model
- Longitudinal Magnetization
Unlike saturation recovery (SR) preparation, IR-prep is sensitive to cardiac arrhythmias. The purpose of this paper is to describe an arrhythmia insensitive IR-prep method that is suitable for clinical applications such as myocardial viability imaging.
All experiments were performed on a 1.5 T MR scanner (Philips Healthcare), and a patch was created with the following changes. The TI necessary to null the signal from a specific tissue is given by: TI = ln(2/(1+exp(-RR/T1)))*T1. The TI for each shot of the IR-TFE shot was adaptively adjusted in real-time based on the record of the most recent RR interval.
An agarose gel phantom mimicking the LV cavity and the surrounding was designed, and imaged using an IR-TFE sequence with the following parameters: TR/TE/α = 5.1/2.5/15°ms; Voxel-size: 1.6*1.6*8 mm; TFE factor = 14; BW/pixel = 309 Hz. Total scan duration: 18 RR intervals. Arrhythmias mimicking clinical reality were generated using a software driven ECG synthesizer.
Representative IR-TFE images acquired without any arrhythmias and with arrhythmias without adaptive TI correction, and with adaptive TI correction are shown in Figure (1C, D and 1E - left to right). Note the substantial reduction in the ghosting artifacts in the image with adaptive TI correction. The myocardial-to-blood CNR was 73% lower without adaptive TI correction than with TI correction. The ghost artifact intensities dropped by 180% with adaptive TI correction when compared with intensities measured without adaptive TI.
The results from the study show that it is feasible to diminish artifacts arising from arrhythmias in an IR-TFE sequence by adaptively adjusting the TI in real-time based on the most recent RR interval. The elimination of these artifacts can improve the myocardial-to-blood CNR as well as decrease artifact intensity.
This article is published under license to BioMed Central Ltd.