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New insight of CMR in the diagnosis of left ventricular non-compaction: measurement of trabeculated left ventricular mass
© Jacquier et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Introduction: There is no universally accepted definition of left ventricular non compaction (LVNC) at present. Furthermore, investigators recently showed that there was a poor correlation between the 3 echocardiographic definitions of LVNC.
To describe a method for measuring trabeculated left ventricular (LV) mass using cardiac magnetic resonance imaging (CMR) and to assess its value in the diagnosis of LVNC.
The percentage of trabeculated LV mass was almost 3 times higher in the patients with LVNC (32 ± 10 %), compared to those with DCM (11 ± 4 %; P < 0.0001), HCM (12 ± 4 %, P < 0.0001), and controls (12 ± 5 %; P < 0.0001). A value of trabeculated LV mass above 20% of the global mass of the LV predicted the diagnosis of LVNC with a sensitivity of 93.7% (95% CI: 71.6%-98.8%) and a specificity of 93.7% (95% CI: 83.1%-97.8%; κ = 0.84).
The method described is reproducible and provides an assessment of the global amount of LV trabeculation. A trabeculated LV mass above 20% of the global LV mass is highly sensitive and specific for the diagnosis of LVNC.
This article is published under license to BioMed Central Ltd.