Diastolic untwisting is altered in patients with congenital heart disease: a novel MR speckle tracking method for cine-MRI
© Niemann et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
In patients with CHD (CO, ASD, VSD and ToF) satisfactory post-op outcome is not solely dependent on systolic RV and LV function. Early signs of LV diastolic dysfunction might need to be emphasized in this patient group.
We used a novel MR speckle tracking method for MR gradient-echo loops to evaluate the LV for early signs of diastolic dysfunction, namely length of LV diastolic untwisting.
We studied 15 pts with TOF (6 mon-45 y) post repair, 15 pts with ASD, VSD and CO (5 y-37 y) and 8 healthy adults (24-35 y). MR images were acquired with an ECG gated 1.5/3 T Magnet with segmented gradient-echo cine-loop sequences (short/long/rotated axis) to cover the entire RV and LV. Images were analyzed offline by VVI (Siemens). RV size and function was correlated for each patient). LV myocardial strain, direction of twist and untwisting, time to peak twist and length to peak diastolic untwisting were measured and compared for each patient.
Not only the degree and length of systolic twist are affected in CHD post-op pts but also time to peak and length of diastolic untwisting. These findings could help evaluate the LV for early alterations in this pt group independent of LV systolic function.
This article is published under license to BioMed Central Ltd.