- Poster presentation
- Open Access
- Published:
Free breathing myocardial perfusion MRI with SW-CG-HYPR using motion correction
Journal of Cardiovascular Magnetic Resonance volume 12, Article number: P205 (2010)
Introduction
The diagnostic value of first-pass perfusion MRI is limited by the low spatial coverage, resolution, SNR, and motion artifacts. Sliding-Window Conjugate-Gradient HYPR [1] (SW-CG-HYPR) has been proposed to acquire perfusion images with increased spatial coverage, better spatial resolution, and improved SNR [2]. However, this method is sensitive to the respiratory motion and thus limited to the breath hold. Motion correction may be useful to reduce motion artifacts and allow for free-breathing first-pass perfusion.
Purpose
To develop and test a non-model-based motion correction method combined with SW-CG-HYPR to perform free-breathing myocardial MR imaging.
Methods
An ECG-triggered, multi-slice FLASH sequence with radial sampling was used. As shown in Figure 1, radial sampling was applied in a segmented interleaved fashion. Multiple slices were acquired after each saturation recovery pre-pulse. The motion correction method is illustrated in Figure 2. Both translation and rotation of the heart were detected in image domain by calculating the normalized cross-correlation coefficients. Motion correction was performed in k-space by rotating the undersampled k-space and shifting the phase by a factor of exp(-2πi(δx/Nread+δy/Npe)), where δx and δy are the number of pixels to shift in × and y direction, and Nread and Npe are the total number of pixels along readout and phase encoding direction. Sliding window was used to reconstruct the composite images, and the time-resolved images were reconstructed after CG-HYPR processing. Six healthy volunteers were scanned using a 1.5 T system, with and without breath hold, during first-pass of the contrast agent. Imaging parameters included: TR/TE/flip-angle = 3.2/1.6 ms/10º, spatial resolution = 1.3 × 1.3 × 10 mm3, and number of slices = 6. The images were qualitatively graded by a reviewer using a score of 1-4 (1: worse; 4: best), and the signal changes vs. time curves were compared.
Schematic of the myocardial perfusion acquisitions sequence. Radial k-space is highly undersampled, interleaved and equally space. Mulitple slices are acquired after each SR preparation pulse. In this work, two slices were acquired after each SR pre-pulse, and totally six slices were acquired for each cardiac cycle.
Schematic diagram illustration the motion correction scheme. The ROI (illustrated by the red rectangular) of the low resolution imates (b), reconstructed from the center of the undersampled k-space, is compared with the composite image (without motion correction) (a) for the motion detection. After the motion correction the k-space is the precessed by SW-CG-HYPR method for the time-resolved myocardial perfusion images.
Results
The average image quality score of the free-breathing images with motion correction (3.09 ± 0.37) is significantly higher than those without motion correction (2.26 ± 0.40), and is comparable to the successful breath-holding images (3.10 ± 0.41) (Figure 3). The signal changes in motion corrected free-breathing images were closely related to those in the breath-holding images, with a correlation coefficient of 0.9764 for myocardial signals (Figure 4 and 5).
Conclusion
The image quality of myocardial perfusion MRI using SW-CG-HYPR was substantially improved after motion correction. This technique may allow myocardial perfusion MRI during free breathing.
References
Griswold MA, et al: #834. Proceedings of ISMRM. 2007
Ge L, Li D, et al: Magn Reson Med. 2009, DOI: 10.1002/mrm.22059
Author information
Authors and Affiliations
Rights and permissions
Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Ge, L., Kino, A., Griswold, M. et al. Free breathing myocardial perfusion MRI with SW-CG-HYPR using motion correction. J Cardiovasc Magn Reson 12 (Suppl 1), P205 (2010). https://doi.org/10.1186/1532-429X-12-S1-P205
Published:
DOI: https://doi.org/10.1186/1532-429X-12-S1-P205
Keywords
- Motion Correction
- Breath Hold
- Free Breathing
- Image Quality Score
- Reduce Motion Artifact