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Influence of left ventricular hypertrophy and geometry on diagnostic accuracy of wall motion and perfusion analysis during dobutamine stress magnetic resonance
© Gebker et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Despite the consistently high endocardial border visualization achieved with cine MR imaging, visual identification of developing wall motion abnormalities may be challenging in hypertrophied hearts.
To examine the influence of left ventricular hypertrophy and geometry on the diagnostic accuracy of wall motion and perfusion analysis during high dose dobutamine stress magnetic resonance (DSMR).
Combined wall motion (DSMR) and perfusion imaging (DSMRP) was performed in a single session in 156 patients scheduled for invasive coronary angiography. Patients were classified into four categories based on LV mass (normal ≤81 g/m2 in men, ≤62 g/m2 in women) and relative wall thickness (RWT, normal <0.45): normal geometry, concentric remodeling, concentric hypertrophy and eccentric hypertrophy. Wall motion and perfusion images were interpreted sequentially, blinded to other data. Significant coronary artery disease (CAD) was defined as ≥70% stenosis.
The accuracy of DSMR is influenced by LV mass and geometry. In patients with concentric remodeling and concentric hypertrophy additional first-pass perfusion imaging during high dose dobutamine stress improves the diagnostic accuracy for the detection of CAD.
This article is published under license to BioMed Central Ltd.