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Effects of caffeine abstinence on adenosine induced coronary flow reserve quantified on phase contrast velocity encoded MRI of the coronary sinus
© Carlsson et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Adenosine is a common pharmacological vasodilator agent used in first pass perfusion MRI as well as nuclear cardiology and echocardiography. Coronary flow reserve (CFR) by adenosine is inhibited by caffeine and therefore caffeine abstinence is routinely proscribed in patients. However, the guidelines differ regarding how long abstinence is needed from 12 to 24 hours.
This study was performed to investigate if 12 h caffeine abstinence is enough to provide maximal coronary flow reserve (CFR).
12 healthy individuals (5 females, 39 ± 14 years) were imaged using a 1.5 T Philips Intera CV at rest and during adenosine infusion (140 µg/kg/min) at two occasions, after 12 and 24 h caffeine abstinence respectively. Coronary sinus flow was measured during breath hold with a phase contrast velocity encoded (PC) TFE sequence with 20 phases per cardiac cycle. Typical imaging parameters were: SENSE factor 2, TE/TR/flip: 3.1/4.8 ms/15º, turbo factor 5, spatial resolution 1.2 × 1.2 × 7 mm and VENC 80 cm/s. CFR was calculated as the ratio between coronary sinus flow/min at adenosine and rest. Cardiac output was measured using PC-MRI of the ascending aorta.
Twelve hours caffeine abstinence results in a lower coronary flow reserve compared to 24 hours and there is a large inter-individual difference to caffeine abstinence. This needs to be taken into consideration when performing adenosine perfusion imaging studies.
This article is published under license to BioMed Central Ltd.