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Novel high resolution method for visualization of regional ventricular wall motion and blood flow by 3 T MRI
© Samnøy et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Alteration in myocardial wall motion may be related to e.g. coronary artery disease. Dysfunctional wall motion may also influence on the blood flow pattern throughout the cardiac cycle. Assessing the wall motion and blood flow is therefore important for detecting regional left ventricular dysfunction and abnormal flow patterns.
Using a time-resolved 3D MRI velocity mapping technique, the aim of this study was to develop an improved tool for quantification and visualization of both regional ventricular wall motion and the corresponding intracavity blood flow pattern.
Three dimensional phase shift velocity mapping were utilized to obtain velocity measurements from the left ventricular wall and the intracavity blood. The scanner used for the acquisitions was a 3.0 T GE Signa Excite, and sequence parameters were TR = 11 ms, TE = 4 ms, Flip Angle = 20, Slice Thickness = 8 mm, Matrix = 128 × 256. Data from a full 3D volume were acquired to carry out the velocity mapping technique on successive slices covering the entire left ventricle throughout the cardiac cycle.
By adding three separate velocity components in every pixel the resultant vector was constructed to get the true 3D direction and velocity throughout the cardiac cycle. Software based on Java has been developed for the quantification and visualization of the 3D velocity vectors. The velocity pattern for both the ventricular wall and blood flow were superimposed on transparent images and visualized in a fully rotatable and scalable 3D frame. The length and color of the 3D vectors visualize the strength and direction of the movement at every voxel.
This software utilizes 3D MRI velocity mapping and improves the ability to study simultaneously regional velocity patterns of the left ventricle and the corresponding intracavity blood velocity pattern. The visualization technique reflects time-dependent velocities and reveal regional difference in tissue blood reserve and function, and also in the blood velocity pattern. Moreover, the technique may reveal hypokinetic and akinetic contractions, as well as asyncronous and dyskinetic wall movements.
This article is published under license to BioMed Central Ltd.