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Regional matrix metalloproteinase activation correlates with microstructure diffusion tensor indices post myocardial infarction
© Mekkaoui et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Post myocardial infarction (MI) activated matrix metalloproteinases (MMPs) degrade the extracellular matrix (ECM) and alter the tissue microstructure (TMS). Diffusion Tensor MRI (DT-MRI) yields diffusivity and anisotropy indices that characterize the TMS. Our previous studies in pigs post-MI have showed that gross spatial and temporal changes in mean diffusivity () and fractional anisotropy (FA) correlate with MMP activation assessed with a 99 mTc-labeled radiotracer (RP805) targeted at activated MMPs.
To determine the correlation between regional MMP activation defined by RP805 with alterations in, FA and a new coefficient of anisotropy, the toroidal curvature (TC).
Therefore, MMP-mediated degradation of the ECM post-MI was associated with increased water diffusivity as reflected by and reduced anisotropy by a decrease in FA and TC. Hence, evaluation of regional DT-MRI indices of microstructure in combination with evaluation of MMP activation may provide new insight in the remodeling process post-MI.
This article is published under license to BioMed Central Ltd.