Volume 12 Supplement 1
Validation of a fast method for quantifying left ventricular torsion
© Reyhan and Ennis; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
To develop and validate a quantitative method, requiring limited user interaction, for the fast calculation of left ventricular (LV) torsion.
LV torsion is an important measure of LV performance [1, 2]. Torsion is the difference in the angle of rotation between apical and basal slices. Rotations in image space directly correspond to rotations in Fourier space; therefore it is possible to exploit this property and measure LV torsion in k- space.
Short-axis tagged images were acquired at 1.5 T in six beagle dogs using the 3D fast gradient echo pulse sequence with the following parameters: 180 × 180 × 128-160 mm field of view (FOV), 384 × 128 × 32 acquisition matrix, 12° imaging flip angle, ± 62.5 kHz receiver bandwidth, TE/TR = 3.4/8.0 ms, and five pixel tag spacing. Tissue tags in two short axis slices were tracked semi-automatically using the FindTags  software to define "gold standard" results.
Tissue Tag Tracking
Estimates of LV rotation at each slice level in each time frame were obtained from the rotation of horizontal and vertical tag intersections about the LV centroid determined using FindTags.
k-space Cross Correlation
The only user interaction needed for processing is contouring of the LV epicardium in the first time frame. After masking, the LV epicardial edge was smoothed to reduce ringing in k-space before Fourier transformation. The k-space magnitude data for each frame was 2D cross-correlated with a rotated version (-1° to 1° with step-size of 0.25°) of the frame immediately after it within the same slice. The maximum of the cross-correlation from all tested rotations defined the angle of rotation between the first frame and each subsequent frame.
We have developed a fast, user friendly, and accurate algorithm for computing global LV torsion. Refinements in image acquisition and k-space processing should improve the overall accuracy.
This article is published under license to BioMed Central Ltd.