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  • Open Access

Patient-specific changes in rv function by CMRI in Tetralogy of Fallot patients prior to pulmonary valve replacement

  • 1,
  • 1,
  • 1,
  • 1,
  • 2 and
  • 2
Journal of Cardiovascular Magnetic Resonance201012 (Suppl 1) :P26

https://doi.org/10.1186/1532-429X-12-S1-P26

  • Published:

Keywords

  • Pulmonary Regurgitation
  • Pulmonary Valve Replacement
  • Monitor Disease Progression
  • Progression Pattern
  • Initial Repair

Introduction

Survival rates for children with tetralogy of Fallot (TOF) following initial repair are excellent but susceptible to varying long-term outcome. Current management uses clinical and imaging parameters to determine need and timing for pulmonary valve replacement (PVR) surgery. At present, no consensus exists on the preferred protocol or best criteria. Clinical imaging studies, in the TOF population, have shown deterioration in ventricular function prior to surgery and improvement following surgery. However, few serial imaging studies prior to PVR have been published to date. In this IRB approved study, we investigated progression of ventricular function parameters in 31 children with TOF, who underwent serial (two or more) MRI studies.

Methods

We examined 31 patients (16 M, 15 F) in serial MRI studies post repair and prior to PVR. The patients at time of initial MRI were 2 to 21 years of age (mean 11) and 0.6 to 5.4 years (mean 3) between the first and last MRI scan. The following cardiac function parameters were evaluated for both ventricles: ejection fraction (EF), cardiac output (CO), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and pulmonary regurgitation (PR). All values except EF were normalized to body surface area. The interval change amount was normalized by the time between studies to show change per year.

Results

Review of the serial studies showed (mean value) decline in cardiac function in most parameters in a direction consistent with known disease progression patterns in TOF. However, changes are not significantly different from zero for all parameters in these patients and measurements. We observed significant change in RVESV (p = 0.045), RVEDV (p = .003), RVSV (p = .017), and a PR (p = .016). Table 1 shows changes per year in all observed ventricular function parameters. Figure 1 shows a histogram of the changes per year in RVEDV, where we found the highest significance in the change per year.
Table 1

Mean, Standard Error of the mean, and p-value of volumetric ventricular function parameters for MRI

 

Mean

Standard Error

p-value

RV EF

-0.432

1.136

0.353

RV CO

0.143

0.138

0.155

RV ESV

3.575

2.011

0.043

RV EDV

6.657

2.199

0.003

RV SV

3.236

1.459

0.017

LV EF

-1.097

1.058

0.154

LV CO

-2.081

2.077

0.162

LV ESV

1.807

1.341

0.094

LV EDV

2.206

1.372

0.059

LV SV

0.260

0.739

0.364

RR

4.450

1.986

0.016

Figure 1
Figure 1

Histogram of the distribution of the changes (per year) in RVEDV for the 31 patients.

Conclusion

Serial MRI imaging is capable of showing an increase in volume load and decline in right ventricular function useful in monitoring disease progression in TOF post initial repair. The study supports the clinical significance of RVEDV as a more sensitive parameter for observing disease progression.

Authors’ Affiliations

(1)
Emory University, Atlanta, GA, USA
(2)
Children's Healthcare of Atlanta, Atlanta, GA, USA

Copyright

© Gandhi et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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