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Patient-specific changes in rv function by CMRI in Tetralogy of Fallot patients prior to pulmonary valve replacement
© Gandhi et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Survival rates for children with tetralogy of Fallot (TOF) following initial repair are excellent but susceptible to varying long-term outcome. Current management uses clinical and imaging parameters to determine need and timing for pulmonary valve replacement (PVR) surgery. At present, no consensus exists on the preferred protocol or best criteria. Clinical imaging studies, in the TOF population, have shown deterioration in ventricular function prior to surgery and improvement following surgery. However, few serial imaging studies prior to PVR have been published to date. In this IRB approved study, we investigated progression of ventricular function parameters in 31 children with TOF, who underwent serial (two or more) MRI studies.
We examined 31 patients (16 M, 15 F) in serial MRI studies post repair and prior to PVR. The patients at time of initial MRI were 2 to 21 years of age (mean 11) and 0.6 to 5.4 years (mean 3) between the first and last MRI scan. The following cardiac function parameters were evaluated for both ventricles: ejection fraction (EF), cardiac output (CO), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and pulmonary regurgitation (PR). All values except EF were normalized to body surface area. The interval change amount was normalized by the time between studies to show change per year.
Mean, Standard Error of the mean, and p-value of volumetric ventricular function parameters for MRI
Serial MRI imaging is capable of showing an increase in volume load and decline in right ventricular function useful in monitoring disease progression in TOF post initial repair. The study supports the clinical significance of RVEDV as a more sensitive parameter for observing disease progression.
This article is published under license to BioMed Central Ltd.