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Multi-organ involvement assessed by MRI in patients with thrombotic thrombocytopenic purpura
Journal of Cardiovascular Magnetic Resonance volume 12, Article number: P263 (2010)
Thrombotic Thrombocytopenic Purpura (TTP) is an uncommon, acquired, life threatening, autoimmune disorder characterised by multi-organ involvement with microvascular occlusion. Although autopsy studies have shown high incidence of cardiac involvement, clinical evidence of cardiac disease is limited.
We hypothesised that, in TTP: 1) CMR would detect otherwise unrecognized cardiac involvement and 2) this involvement would correlate with other organ involvement.
Thirteen consecutive patients (4 males, 9 females, mean age: 47 ± 13 years), enrolled as part of an observational study, were evaluated with standard cardiac and brain magnetic resonance. The late gadolinium enhancement (LGE) technique was used to assess areas of cardiac focal fibrosis potentially caused by micro-thrombotic damage.
All patients had normal LV ejection fraction (mean EF 66 ± 5%). LV volumes and mass were normal in 11 of 13 patients and raised in 2. No patient had regional wall motion abnormalities. Three patients (23%) had patches of LGE which were sub-endocardial and limited in size (Figure 1a and 1b). By contrast, only two patients had a completely normal brain MRI. Four had supratentorial white matter lesions; seven had cerebellar/deep grey matter/subcortical/cortical infarcts (Figure 1c and 1d). All three patients with LGE had severe brain involvement. The extent of brain damage correlated with the presence of cardiac LGE (Kendall's tau-c = 0.43, p = 0.023).
In this pilot study looking at cardiac involvement in TTP by CMR, CMR found LGE patches in one quarter of patients (without wall motion abnormalities). LGE was more likely to be found if there was more severe brain involvement.
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Quarta, G., Scully, M., Harpreet, H. et al. Multi-organ involvement assessed by MRI in patients with thrombotic thrombocytopenic purpura. J Cardiovasc Magn Reson 12, P263 (2010). https://doi.org/10.1186/1532-429X-12-S1-P263
- Late Gadolinium Enhancement
- Regional Wall
- White Matter Lesion
- Wall Motion Abnormality
- Organ Involvement