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CMR assessment of epicardial fat volume in human morbid obesity at 3 T: relationship to cardiac function and morphology
© Gaborit et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Ectopic fat accumulation within and around the myocardium is involved in the pathogenesis of obesity-related cardiomyopathy and cardiovascular disease. Earlier MR studies have been restricted to a mildly obese population due to magnet bore size limitations. For this study, a 70 cm bore 3 tesla MR system offered the possibility to assess left-ventricular (LV) morphology and function along with EFV in patients with severe obesity.
To assess epicardial fat volume (EFV) in severely obese patients with CMR at 3 T, and to determine its potential correlations with left-ventricular function and morphology.
CMR was performed with a Siemens Verio 3 T system in 24 obese patients (15 with morbid obesity and 9 with diabetes, mean BMI = 42.3 ± 5.7 kg/m2) and in 14 healthy controls (mean BMI = 22.4 ± 2.1 kg/m2). The scanner was equipped with a 32-channel phased-array coil. Sixteen short-axis slices covering the heart and its surrounding adipose tissue were obtained within four breathholds using a balanced SSFP cine sequence with 4-fold GRAPPA k-space reduction (FOV = 340 × 340 mm2, TE = 1.2 ms, TR = 61 ms, matrix = 134 × 192, slice thickness 6 mm). The absolute volume of epicardial fat was assessed by manual delineation on every slice from base to apex. Parameters of LV function and morphology were obtained using the same short-axis dataset. All patients underwent an intraabdominal CT scan for visceral adipose tissue (VAT) assessment and biological evaluation.
CMR at 3 T allowed quantification of epicardial fat volume and LV morphology and function in severely obese subjects. A significant correlation was shown between LV function and EFV.
This article is published under license to BioMed Central Ltd.