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- Open Access
Preferential patterns of myocardial iron deposit by multislice multiecho T2* CMR in thalassemia major patients
© Positano et al; licensee BioMed Central Ltd. 2010
- Published: 21 January 2010
- Cardiac Magnetic Resonance
- Iron Overload
- Iron Deposit
- Thalassemia Major
T2* multislice multiecho cardiac magnetic resonance (CMR) technique has permitted quantification of myocardial iron burden by a segmental approach. Little is known in the literature about patterns of iron store in hemochromatosis.
Our study aimed to investigate myocardial iron overload in thalassemia major (TM) patients by segmental T2* CMR technique, in order to determine if there were preferential patterns of iron deposit.
Five hundred and nineteen TM patients underwent CMR. Three short-axis views (basal, medium, and apical) of the left ventricle were acquired and analyzed using custom-written, previously validated software. The myocardium was automatically segmented into a 16-segment standardized LV model and the T2* value on each segment was calculated, as well as the global T2* value. Four different main circumferential regions (anterior, septal, inferior and lateral) were defined by averaging the corresponding segmental T2* values.
A preferential pattern of iron store in anterior and inferior regions appears to be present in TM patients with severe and mild-moderate iron overload. The preserved pattern between the groups prevents attributing this datum to additive susceptibility artefacts, which are negligible in heavily iron-loaded patients. A segmental T2* CMR approach could identify early iron deposit, useful for tailoring chelation therapy and preventing myocardial dysfunction in the clinical setting.
This article is published under license to BioMed Central Ltd.