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The Gootter registry. Guiding our outcomes to terminal electrical rhythms - A CMR study of ICD events


Sudden cardiac death (SCD) remains a major health problem, accounting for nearly 1000 deaths in the US daily. Clinical trials have proved a survival benefit with ICD implantation in patients with a LVEF <30-35%. However, it has been estimated that of the 2 million ICD's currently implanted, only 5% ever fire to correct a deadly arrhythmia. Also, many patients who would benefit from a prophylactic ICD are not considered candidates for implantation suggesting our criteria are inaccurate. Clearly, an accurate predictor of deadly cardiac arrhythmias has yet to be identified.


Cardiac MRI (CMR) is noninvasive, non-irradiating, and can identify even small regions of LV myocardial fibrosis. These investigators believe that this micro-fibrosis is the common underlying substrate for deadly arrhythmias from multiple ischemic and non-ischemic etiologies.


This study was approved by the IRB. All patients receiving ICD for either primary or secondary prevention were enrolled. Comprehensive CMR examination (1.5 T GE Sigma v14x) including myocardial delayed contrast enhancement (E) was performed in 42 patients over a period of 3 years (185 patients were screened and 143 were excluded for patient refusal, pacer or ICD leads, unable to schedule prior to ICD implantation, and claustrophobia). Patients were followed routinely in the ICD clinic and monitored for appropriate ICD shocks or anti-tachycardia pacing (ATP), ventricular tachycardia () and cardiac death (primary end-points). Secondary end-points included non-sustained (NS), supraventricular tachycardia (S), and non-cardiac death. Continuous variables were expressed as mean + SD. CMR findings in patients without events yet to be analyzed.


Mean age is 59 +/- 12 years. 41/42 patients available for follow-up (480 +/- 300 days). ICD implantation performed within 12 + 18 days after CMR. There were 37 primary and 5 secondary prevention implants. 7(17%) patients experienced primary (N = 3) or secondary (N = 4) end-points. Of these, 3 had >10% and 3 had < 10% ratio of E/LV mass. 1(17%) patient had an endocardial (CAD) E pattern and 5(83%) a non-CAD E pattern. There were 2 deaths, 1 pulmonary embolism and 1 SCD (<24 hours after CMR prior to ICD), Table 1.

Table 1 Characteristics of 7 patients with episodes


This is an early report from the GOOTTER registry on patients with short term events after ICD implantation. 7(17%) endpoints have occurred. 3(7.7%) had a primary event (1 death) >1 year follow up.

LVEF was a poor discriminator for SCD prediction. Fibrosis is a common denominator for a deadly arrhythmia substrate as seen in all the patients with events even those who have a preserved LVEF.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kalra, N., Sorrell, V.L. The Gootter registry. Guiding our outcomes to terminal electrical rhythms - A CMR study of ICD events. J Cardiovasc Magn Reson 12 (Suppl 1), P300 (2010).

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