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Effect of contrast dosage on image quality of MR angiography and Late Gadolinium enhancement imaging of the left atrium
© Vijayakumar et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
MR angiography (MRA) of left atrium (LA) is performed to provide an anatomical map of the LA for use during RF ablation procedures. High-resolution Late Gadolinium enhancement (LGE) imaging of LA is used to assess the left atrial wall [1, 2] in patients undergoing RF ablation  typically with full (0.1 mmol/kg) doses of contrast (Gd-BOPTA). It is of interest to determine if smaller doses (0.05 mmol/kg) give comparable image quality, especially to image patients with abnormal kidney function.
The average score of the image quality by blinded readers (mean ± std. dev)
Half Dose (MRA)
Full Dose (MRA)
Half Dose (LGE)
Full Dose (LGE)
3.40 ± 0.58
3.50 ± 0.66
2.27 ± 0.99
3.18 ± 0.75
3.38 ± 0.65
3.65 ± 0.48
2.92 ± 0.79
3.50 ± 0.91
Although MRA images at both doses are comparable, half and full dose do not give equivalent LGE image quality. From the Paired Students t-test, the difference in CER's from MRAs is not statistically significant (p = 0.35), but the difference in CNRs from LGE images (CNRsb, CNRsm) is statistically significant (p = 0.01, p = 0.025) respectively. From blinded reader scores, the difference in MRAs is not statistically significant while that of LGE is (p = 0.6, p = 0.04 respectively).
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