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Contrast enhanced magnetic resonance imaging of culprit lesions in patients with acute coronary syndrome
© Jansen et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
X-Ray Angiography (XRA) is the gold standard for the assessment of lumen encroaching coronary stenosis, which typically underlies stable coronary artery disease. However, XRA cannot distinguish between stable and vulnerable plaques, which are thought to be the precursor lesions of most acute myocardial infarctions (MI) and death. The development of a non-invasive technique that can detect culprit lesions immediately after MI may eventually prove useful for prospective identification of vulnerable plaque.
The aim of the study was to evaluate whether contrast-enhanced magnetic resonance imaging (CE-MRI) could detect culprit lesions in patients with a recent ACS (troponin T >1.0).
16 patients (14 male, age 62.7 ± 8.7) were imaged within 24-72 h after presenting with ACS prior to XRA. Following coronary lumen imaging and contrast injection, CE-MRI of the coronary artery wall was performed using a T1-weighted 3D gradient echo inversion recovery sequence (3D IR TFE).
CE-MRI allows selective visualization of culprit lesions in patients after MI. This technique may be useful for prospective detection of vulnerable plaque.
This article is published under license to BioMed Central Ltd.