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Contrast-enhanced whole heart coronary MRI with a bolus infusion of gadobenate dimeglumine at 1.5 t
Journal of Cardiovascular Magnetic Resonance volume 12, Article number: P51 (2010)
The potential benefits of contrast agents have been studied for coronary MRI; however the contrast timing/injection rate and sequence remain to be optimized. We investigated three infusion schemes (bolus, hybrid, slow) of gadobenate dimeglumine ([Gd-BOPTA]2-, MultiHance; Bracco Imaging SpA, Milan, Italy), a high relaxivity extracellular contrast agent, for improved whole-heart coronary MRI by measuring blood T1 kinetics. Subsequently, we developed a contrast-enhanced whole-heart coronary MRI method at 1.5 T using an inversion-recovery SSFP sequence acquired after a bolus infusion.
Four healthy adult subjects were imaged three times each using three infusion schemes: a) bolus (0.2mmol/kg@2ml/s), b) hybrid (0.1mmol/kg@2ml/s plus firstname.lastname@example.org/s), and c) slow (0.2mmol/kg@ 0.3ml/s). A Look-Locker sequence was used for quantitative T1 measurements. Subsequently, seven healthy subjects were recruited for evaluation of a contrast-enhanced whole-heart coronary MRI with a bolus infusion. Free-breathing SSFP coronary MRI (TR/TE/α = 3.6/1.8/90°, FOV = 300 × 300 × 120 mm3, resolution = 1.3 × 1.3 × 1.3 mm3, T2-Prep, ×2 accelerated) was performed before contrast injection. Gd-BOPTA (0.2mmol/kg@2ml/s) was injected intravenously, immediately followed by a Look-Locker sequence to visually determine the optimal inversion time. A contrast-enhanced whole-heart coronary was then acquired with identical imaging parameters with the exception of replacing the T2-Prep with a non-selective inversion pulse. For both acquisitions, a noise scan was performed immediately after acquisition. The blood SNR and blood-myocardium CNR were measured.
Figure 1 shows the blood T1 during the first 10 min after contrast injection. The bolus injection yields the fastest and largest T1 reduction in the initial 1-2 minutes. Slow infusion reduces the T1 at a slower pace than bolus, but was similar to bolus ∼ 2-3 min after injection. A hybrid infusion results in the lowest decrease in T1, but also the most stable. Figure 2 shows a comparison of contrast-enhanced and non-contrast coronary images. The coronary SNR and CNR were significantly improved by 36% (58.5 ± 18.7 vs. 79.5 ± 17.5) and 101% (27.3 ± 11.4 vs. 55.0 ± 12.1), respectively (p < 0.003 for both). Figure 3 shows reformatted examples of the LAD, which shows improved visualization of mid and distal LAD.
Contrast-enhanced whole heart coronary MRI with a bolus infusion of Gd-BOPTA using inversion-recovery SSFP at 1.5 T results in enhanced SNR and CNR.
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Hu, P., Chan, J., Smink, J. et al. Contrast-enhanced whole heart coronary MRI with a bolus infusion of gadobenate dimeglumine at 1.5 t. J Cardiovasc Magn Reson 12, P51 (2010). https://doi.org/10.1186/1532-429X-12-S1-P51
- Infusion Scheme
- Bolus Infusion
- Gadobenate Dimeglumine
- Healthy Adult Subject
- SSFP Sequence