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Coronary microemboli have long-term effects on regional left ventricular function: MRI 3D strain analysis
© Jablonowski et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Microembolization is common during coronary intervention in patients. The long-term effects of microemboli on regional 3D strain and global left ventricular (LV) function have not been examined.
This experimental study investigated whether coronary microemboli have long-term deleterious effects on LV function using MRI strain analysis.
A hybrid X-ray and MRI system was used to catheterize the LAD in 6 pigs and deliver the embolic materials (40-120 μm, 250,000 count). The area at risk (AAR) was determined on first-pass perfusion (FPP) MRI before and after microembolization. Delayed enhancement (DE)-MRI and histochemical staining were used to visualize and measure microinfarcts. Analysis of longitudinal strain was performed on phase-contrast MRI and radial strain as well as global function on ssfp MRI using Segment http://segment.heiberg.se. Tagged MRI were analyzed to measure circumferential strain using HARP. The Student's t-test was used to determine if strain over the cardiac cycle differed between baseline, acute (1 h) and chronic phases (7-8 weeks).
This serial MRI study demonstrated a persistent regional LV dysfunction in the microembolized area. Regional 3D strain measurements may be useful in predicting decreased contractility in the LV in patients with biomarker release after coronary intervention.
* P < 0.05, *** P < 0.001 compared to baseline and † p < 0.05 compared with AAR at the same stage.
This article is published under license to BioMed Central Ltd.