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Prediction of response to cardiac resynchronization therapy by cine- and velocity encoded cardiac magnetic resonance imaging

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Journal of Cardiovascular Magnetic Resonance201012 (Suppl 1) :P63

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  • Magnetic Resonance Imaging
  • Heart Failure
  • Ejection Fraction
  • Clinical Response
  • Cardiac Magnetic Resonance


Quantification of mechanical dyssynchrony can help to identify responders to cardiac resynchronization therapy (CRT).


The purpose of the present study was to evaluate the ability of cine- and velocity encoded (VENC) magnetic resonance imaging (MRI) to predict response to CRT.


The study included twenty patients with heart failure NYHA class III and reduced ejection fraction (24 (18-28) %), scheduled for CRT device implantation. All patients underwent cine- and VENC-MRI before device implantation. Intra-ventricular dyssynchrony was measured by cine-MRI as the septal-to-lateral mechanical delay (SLMD). The inter-ventricular mechanical delay (IVMD) was assessed by VENC-MRI as the difference between onset of aortic and pulmonary flow. Clinical response to CRT was assessed at 6-month follow-up after device implantation.


Fourteen (70%) patients were classified as clinical responders to CRT. The SLMD and IVMD were longer in responders (336 (165-389) ms and 78 (25-105) ms) than in non-responders (49 (-25-335) ms and 9 (0-31) ms) to CRT (P = 0.05 and 0.02, respectively). Cine-MRI yielded an area under the curve of 0.79 (P = 0.05) to predict response to CRT by measurements of SLMD. The area under the curve was 0.83 (P = 0.02) to predict response to CRT by VENC-MRI measurements of IVMD. Figure 1 demonstrates measurements of IVMD by VENC-MRI in a responder (IVMD = 92 ms, figure 1A) and a non-responder (IVMD = 25 ms, figure 1 B) to CRT.

Figure 1


Cine- and VENC-MRI have the ability to identify responders to CRT.

Authors’ Affiliations

University Medical Center Hamburg-Eppendorf, Hamburg, Germany


© Muellerleile et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.