Skip to main content

Prediction of response to cardiac resynchronization therapy by cine- and velocity encoded cardiac magnetic resonance imaging


Quantification of mechanical dyssynchrony can help to identify responders to cardiac resynchronization therapy (CRT).


The purpose of the present study was to evaluate the ability of cine- and velocity encoded (VENC) magnetic resonance imaging (MRI) to predict response to CRT.


The study included twenty patients with heart failure NYHA class III and reduced ejection fraction (24 (18-28) %), scheduled for CRT device implantation. All patients underwent cine- and VENC-MRI before device implantation. Intra-ventricular dyssynchrony was measured by cine-MRI as the septal-to-lateral mechanical delay (SLMD). The inter-ventricular mechanical delay (IVMD) was assessed by VENC-MRI as the difference between onset of aortic and pulmonary flow. Clinical response to CRT was assessed at 6-month follow-up after device implantation.


Fourteen (70%) patients were classified as clinical responders to CRT. The SLMD and IVMD were longer in responders (336 (165-389) ms and 78 (25-105) ms) than in non-responders (49 (-25-335) ms and 9 (0-31) ms) to CRT (P = 0.05 and 0.02, respectively). Cine-MRI yielded an area under the curve of 0.79 (P = 0.05) to predict response to CRT by measurements of SLMD. The area under the curve was 0.83 (P = 0.02) to predict response to CRT by VENC-MRI measurements of IVMD. Figure 1 demonstrates measurements of IVMD by VENC-MRI in a responder (IVMD = 92 ms, figure 1A) and a non-responder (IVMD = 25 ms, figure 1 B) to CRT.

figure 1

Figure 1


Cine- and VENC-MRI have the ability to identify responders to CRT.

Author information

Authors and Affiliations


Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Muellerleile, K., Baholli, L., Groth, M. et al. Prediction of response to cardiac resynchronization therapy by cine- and velocity encoded cardiac magnetic resonance imaging. J Cardiovasc Magn Reson 12 (Suppl 1), P63 (2010).

Download citation

  • Published:

  • DOI:


  • Magnetic Resonance Imaging
  • Heart Failure
  • Ejection Fraction
  • Clinical Response
  • Cardiac Magnetic Resonance