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Prediction of response to cardiac resynchronization therapy by cine- and velocity encoded cardiac magnetic resonance imaging

  • Kai Muellerleile1,
  • Loant Baholli1,
  • Michael Groth1,
  • Katharina Koopmann1,
  • Achim Barmeyer1,
  • Ralf Koester1,
  • Gerhard Adam1,
  • Gunnar K Lund1 and
  • Stephan Willems1
Journal of Cardiovascular Magnetic Resonance201012(Suppl 1):P63

Published: 21 January 2010


Magnetic Resonance ImagingHeart FailureEjection FractionClinical ResponseCardiac Magnetic Resonance


Quantification of mechanical dyssynchrony can help to identify responders to cardiac resynchronization therapy (CRT).


The purpose of the present study was to evaluate the ability of cine- and velocity encoded (VENC) magnetic resonance imaging (MRI) to predict response to CRT.


The study included twenty patients with heart failure NYHA class III and reduced ejection fraction (24 (18-28) %), scheduled for CRT device implantation. All patients underwent cine- and VENC-MRI before device implantation. Intra-ventricular dyssynchrony was measured by cine-MRI as the septal-to-lateral mechanical delay (SLMD). The inter-ventricular mechanical delay (IVMD) was assessed by VENC-MRI as the difference between onset of aortic and pulmonary flow. Clinical response to CRT was assessed at 6-month follow-up after device implantation.


Fourteen (70%) patients were classified as clinical responders to CRT. The SLMD and IVMD were longer in responders (336 (165-389) ms and 78 (25-105) ms) than in non-responders (49 (-25-335) ms and 9 (0-31) ms) to CRT (P = 0.05 and 0.02, respectively). Cine-MRI yielded an area under the curve of 0.79 (P = 0.05) to predict response to CRT by measurements of SLMD. The area under the curve was 0.83 (P = 0.02) to predict response to CRT by VENC-MRI measurements of IVMD. Figure 1 demonstrates measurements of IVMD by VENC-MRI in a responder (IVMD = 92 ms, figure 1A) and a non-responder (IVMD = 25 ms, figure 1 B) to CRT.
Figure 1

Figure 1


Cine- and VENC-MRI have the ability to identify responders to CRT.

Authors’ Affiliations

University Medical Center Hamburg-Eppendorf, Hamburg, Germany


© Muellerleile et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.