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CMR analysis of global and regional left ventricular function in a single breath-hold
© Eberle et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
Cardiac magnetic resonance (CMR) steady-state free precession (SSFP) images are the reference standard for measuring left ventricular function (LVF) using section summation of short axis images and for analysis of regional wall motion abnormalities (RWMA). Acceleration of this multiple (typically 10-15) breath-hold approach is desirable. Temporal Parallel Acquisition Technique (TPAT) acceleration allows for acquisition of a complete short axis stack in a single breath-hold with limited resolution.
To evaluate global and regional LVF analysis of single breath-hold image stacks acquired with TPAT acceleration, compared with standard imaging.
111 patients (85 male, mean age 54.4 ± 16.7) undergoing CMR for various indications were enrolled. CMR on a 1.5 T Magnetom Avanto (Siemens Medical Solutions, Germany) included iPAT (Integrated Parallel Acquisition Technique) accelerated SSFP cine imaging (TrueFISP, TR 3 ms, TE 1.5 ms, FA 72°, sl 6 mm, temporal resolution 45 ms, iPAT factor 2), inversion recovery (IR) delayed enhancement imaging using, and further sequences if required.
In a single breath-hold, short axis cines covering the LV were acquired using a TPAT accelerated SSFP sequence (TE 1.1 ms, TR 4.6 ms, FA 72°, sl 8 mm, temporal resolution 45 ms, TPAT factor 3).
For both short axis stacks, LVF was analyzed by blinded observers using section summation (Argus, Siemens Medical Solutions, Germany). RWMA were assessed using the 17 segment model.
Volumetric results for standard and TPAT imaging (n = 108; mean ± standard deviation)
Pearsons correlation coefficient
Intraclass correlation coefficient
138.8 ± 39.7
137.3 ± 39.4
-1.6 ± 7.9
59.5 ± 37.4
57.8 ± 36.6
-1.8 ± 6.0
59.3 ± 15.1
60.0 ± 15.1
0.7 ± 3.4
138.4 ± 37.0
136.6 ± 36.8
1.9 ± 8.2
Number of AHA LV segments with wall motion abnormalities (n = 108)
TPAT accelerated imaging
Single breath-hold imaging using TPAT acceleration allows for LVF analysis in good agreement with the reference standard, although yielding marginally lower LV volumes and higher LVEF. Reducing costly image acquisition time and improving patient comfort, it may become the method of choice for LVF analysis. Improvement in resolution is desirable for RWMA analysis.
This article is published under license to BioMed Central Ltd.