- Poster presentation
- Open Access
Quantification of 4D left ventricular blood flow organization in normal and failing hearts
© Carlhäll et al; licensee BioMed Central Ltd. 2010
Published: 21 January 2010
To measure the volume and distribution of separate flow components in normal and dysfunctional left ventricles (LV).
The forces created by blood flow dictate a continuous remodeling of cardiac structures. In the normal heart this mechanism interactively creates an optimal geometry for efficient flow . In various cardiac disorders such as LV dysfunction, however, the normal flow organization may be altered, leading to negative remodelling. The description and quantification of the true 4D (3D+time) blood flow organization in dysfunctional LVs remains incomplete.
Components of LV blood flow
Blood that enters and leaves the LV within the same cardiac cycle
Blood that enters but does not leave the LV within the same cardiac cycle
Delayed Ejection Flow
Blood that leaves but does not enter the LV within the same cardiac cycle
Blood that resides in the LV more than two cardiac cycles
Multidimensional flow analysis can measure the compartmentalization of blood transiting the beating LV. The present findings imply that the highly organized flow in and out of normal LVs is demonstrably altered in DCM, even with only moderate LV dilation and dysfunction. Such measures may contribute not only to our understanding of the pathophysiology and diagnosis of disease, but also to the optimization of therapy.
- Richter Y, Edelman E et al: Circulation. 2006, 113: 2679-2682. 10.1161/CIRCULATIONAHA.106.632687.View ArticlePubMedGoogle Scholar
- Heiberg E et al: Comput Cardiol. 2005, 32: 599-602. full_text.Google Scholar
- Eriksson J et al: ISMRM flow workshop. 2009, 47-Google Scholar
- Bolger AF et al: JCMR. 2007, 9: 741-747.Google Scholar
This article is published under license to BioMed Central Ltd.