- Technologist presentation
- Open Access
The concordance rates between left ventricular hypertrophy and right ventricular hypertrophy in patients with hypertrophic cardiomyopathy as diagnosed by CMR with fibrosis imaging
© Grant et al; licensee BioMed Central Ltd. 2010
- Published: 21 January 2010
- Left Ventricular Hypertrophy
- Ventricular Hypertrophy
- Hypertrophic Cardiomyopathy
- Phenotypic Expression
- Myocardial Fibrosis
CMR has become the leading technique to define the clinical impact of hypertrophic cardiomyopathy (HCM) providing complete coverage of both ventricles with high spatial resolution. Gadolinium delayed-hyperenhancement (DHE) accurately identifies regions of myocardial fibrosis. Via CMR, innumerable studies have established that LVH is the predominant phenotypic expression of HCM. It is well known that myocardial fibrosis can occur in HCM patients and is independently linked to a poorer prognosis than those without fibrosis by CMR. The genotypic expressions would appear to affect the entire heart yet, classically, investigations have been limited to the LV, in some part due to inability to image the smaller, thinner RV. Thus, little information is available about the RV in HCM.
We hypothesize there is significant RV involvement in HCM when incorporating a CMR analysis for RV hypertrophy and fibrosis.
Review of all patients referred for HCM was performed. SSFP/DHE was used to diagnose patients with HCM, using gadolinium administration (0.15mmol/kg, MultiHance, Bracco Diagnostics, Princeton,NJ). Post-injection (2/10 minutes) DHE images were obtained using manual T1-weighted, inversion recovery preparations. Regions of myocardium with abnormally high signals were designated as fibrotic. LV/RV mass indices (LVMI/RVMI) were calculated. Fibrosis was semi-quantitatively assessed in both ventricles.
The frequency of RVH/fibrosis in the setting of HCM is surprising in that this phenomenon is rarely, if ever, described. However, given the genetic abnormalities, there is no reason to expect phenotypic expression should be limited to the LV. Interestingly, similar to the LV, the degree of RVH had little predictive power towards the finding of DHE-defined RV fibrosis. When considering HCM, it is important to recognize that the pathology is not limited to the LV and CMR resolution helps remind us of the concordance between the two ventricles.
This article is published under license to BioMed Central Ltd.