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Is infarct location a prediction of valvular enhancement?


Every day in CMR, delayed hyperenhancement (DHE) is utilized for evaluation of the patient’s extent of myocardial damage from an infarction. In the past,following an MI, we have shown that DHE signal may be seen in the post-MI valvular apparati, not limited to the myocardium. Also, dilation of the mitral annulus was noted over time in some patients. However, it is not known if the infarction location influences which valves enhance, in particular, whether there is a local or a global influence on valvular enhancement.


We hypothesize that the location of the infarct does not influence which valves enhance.


One hundred-one (101) post-MI CMR examinations (chronic MI: 97%>6wks;3% acute<6 wks) were retrospectively reviewed for their infarct location, and whether mitral valves (MV), tricuspid valves (TV), and aortic valves (AV) exhibited any DHE signal after the administration of intravenous gadolinium contrast agents, either 0.2 mmol/kg Magnevist (Berlex, Wayne, NJ.) or 0.15 mmol/kg MultiHance (Bracco, Princeton, NJ). The areas observed were anterior, anterior septum, septum, inferior, inferior septum, lateral, anterior lateral, inferior lateral, and apical areas of the myocardium. The location of the infarct was then assigned anatomically to LAD, RCA, and the LCX coronary distributions.


CMR images in 101 patients (72 males, 64.5 ± 29.77 years; 29 females, 62.9 ± 12.87 years) were retrospectively reviewed for infarction location,See Figure 1. Globally, the valves affected were MV (66%), TV (45%) and AV (30%). When analyzed by infarct territory (LAD, RCA and LCX) there was not a trend present showing any significant difference from the global distribution, See Figure 2

figure 1
figure 2


The reason for valvular enhancement status post MI is not clearly understood. Using CMR DHE, and correlating the location of the areas of DHE signal, it suggests that the distribution of valvular enhancement is not influenced by the coronary artery involved. This points to a global rather than regional involvement of the valvular apparati.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Williams, R.B., Doyle, M., Rathi, V.K. et al. Is infarct location a prediction of valvular enhancement?. J Cardiovasc Magn Reson 12 (Suppl 1), T8 (2010).

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