Effects of steroids and angiotensin converting enzyme inhibition on circumferential strain in boys with Duchenne muscular dystrophy: a cross-sectional and longitudinal study utilizing cardiovascular magnetic resonance

Table 1 DMD Patients characteristics

Parameter	Steroid Only (A)(n = 114 )	Steroid plus ACEI_ARB (B)(n = 92 )	P-value
Age (yrs)	10.0 ± 2.4	12.4 ± 3.2	<0.0001
Heart Rate (bpm)	101 ± 19	104 ± 15	0.2498
LVEDV (mL)	82.5 ± 21.8	86.7 ± 24.8	0.2023
LVM (g)	58.6 ± 19.4	62.1 ± 19.8	0.1031
EF (%)	64.2 ± 6.1	62.8 ± 7.5	0.1414
ε_cc (%)	-13.8 ± 1.9	-12.8 ± 2.0	0.0004
Steroid dose (gram/kg/day)	0.7 ± 0.29	0.6 ± 0.22	0.4838
ACE-I dose (gram/kg/day)	N/A	0.16 ± 0.08	N/A
ARB dose (gram/kg/day)	N/A	0.73 ± 0.29	N/A

Abbreviations: ACE-I = Angiontension Converting Enzyme Inhibitor, ARB = Angiotension Receptor Blocker, bpm = beat per minute, Clinic Prior to CMR = Previous Clinic Visit Documenting Medication and Dose Prior to Cardiac Magnetic Resonance Imaging Study, DMD = Duchenne Muscular Dystrophy, ε_cc = Circumferential Strain, EF = Ejection Fraction, LVEDV = Left Ventricular Endiastolic Volume, LVM = Left Ventricular Mass.

ISSN: 1532-429X