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Table 3 Results from Serial CMR Exams Across DMD Treatment Groups

From: Effects of steroids and angiotensin converting enzyme inhibition on circumferential strain in boys with Duchenne muscular dystrophy: a cross-sectional and longitudinal study utilizing cardiovascular magnetic resonance

Group/Patients Time Interval (months) Group A (Steroids); n = 28
Mean = 14.9 ± 5.6
Range = 8.5-29.7
Group B (Steroids plus ACEI/ARB); n = 31
Mean = 15.1 ± 5.9 Range = 8.4-35.8
Group A to B; n = 11
Mean = 15.6 ± 5.9 Range = 5.8-25.5
CMR Study Study 1 Study 2 P-value Study 1 Study 2 P-value Study 1 Study 2 P-value
Age (yrs) 9.30 ± 1.5 10.5 ± 1.6 <0.005 11.7 ± 3.4 12.97 ± 3.4 0.148 10.8 ± 2.5 12.0 ± 2.2 0.252
HR (bpm) 101 ± 21 99 ± 16 0.762 105 ± 14 105 ± 15 0.996 100 ± 14 102 ± 18 0.682
LVEDV (mL) 82.7 ± 19.3 86.5 ± 21.6 0.494 84.9 ± 29.2 90.0 ± 30.8 0.499 85.6 ± 18.6 81.2 ± 15.6 0.556
LVM (g) 57.1 ± 15.1 57.7 ± 16.9 0.890 60.9 ± 21.4 65.0 ± 21.4 0.478 61.3 ± 31.2 60.1 ± 14.0 0.909
EF (%) 64.6 ± 6.3 64.4 ± 5.8 0.906 64.9 ± 6.7 62.2 ± 9.1 0.194 61.2 ± 5.0 63.8 ± 5.8 0.261
εcc (%) -14.3 ± 1.6 -13.7 ± 1.5 0.135 -13.4 ± 1.7 -12.1 ± 1.6 0.007 -13.2 ± 1.8 -11.9 ± 2.7 0.179
  1. Abbreviations: BMP = beat per minute, DMD = Duchenne Muscular Dystrophy, εcc = Circumferential Strain, EF = Ejection Fraction, ACEI = angiotensin converting enzyme inhibitor, ARB = angiotensin receptor blocker, HR = heart rate, LVEDV = Left Ventricular Endiastolic Volume (milliliter), LVM = Left Ventricular Mass (gram).