Table 3 Results from Serial CMR Exams Across DMD Treatment Groups
Group/Patients Time Interval (months) | Group A (Steroids); n = 28 Mean = 14.9 ± 5.6 Range = 8.5-29.7 | Group B (Steroids plus ACEI/ARB); n = 31 Mean = 15.1 ± 5.9 Range = 8.4-35.8 | Group A to B; n = 11 Mean = 15.6 ± 5.9 Range = 5.8-25.5 | ||||||
|---|---|---|---|---|---|---|---|---|---|
CMR Study | Study 1 | Study 2 | P-value | Study 1 | Study 2 | P-value | Study 1 | Study 2 | P-value |
Age (yrs) | 9.30 ± 1.5 | 10.5 ± 1.6 | <0.005 | 11.7 ± 3.4 | 12.97 ± 3.4 | 0.148 | 10.8 ± 2.5 | 12.0 ± 2.2 | 0.252 |
HR (bpm) | 101 ± 21 | 99 ± 16 | 0.762 | 105 ± 14 | 105 ± 15 | 0.996 | 100 ± 14 | 102 ± 18 | 0.682 |
LVEDV (mL) | 82.7 ± 19.3 | 86.5 ± 21.6 | 0.494 | 84.9 ± 29.2 | 90.0 ± 30.8 | 0.499 | 85.6 ± 18.6 | 81.2 ± 15.6 | 0.556 |
LVM (g) | 57.1 ± 15.1 | 57.7 ± 16.9 | 0.890 | 60.9 ± 21.4 | 65.0 ± 21.4 | 0.478 | 61.3 ± 31.2 | 60.1 ± 14.0 | 0.909 |
EF (%) | 64.6 ± 6.3 | 64.4 ± 5.8 | 0.906 | 64.9 ± 6.7 | 62.2 ± 9.1 | 0.194 | 61.2 ± 5.0 | 63.8 ± 5.8 | 0.261 |
εcc (%) | -14.3 ± 1.6 | -13.7 ± 1.5 | 0.135 | -13.4 ± 1.7 | -12.1 ± 1.6 | 0.007 | -13.2 ± 1.8 | -11.9 ± 2.7 | 0.179 |