Time resolved measure of coronary sinus flow following regadenoson administration
© Booker et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
To use velocity encoded phase contrast MRI to determine timing of peak myocardial blood flow to establish when CMR stress perfusion imaging should be performed after injection of regadenoson.
Regadenoson is a selective A2A adenosine receptor agonist recently FDA approved for stress testing. The package insert recommends administration of the radionuclide imaging agent 20 seconds after bolus. Optimal timing of CMR first-pass perfusion imaging has not been established.
CMR was performed on eighteen volunteers with 10-year Framingham risk scores <1% (15 m, 23 ± 7 years) using a 1.5 T Siemens Espree. Serial measures of coronary sinus (CS) and cardiac output (CO) were made using a velocity encoded phase contrast sequence.
Peak myocardial blood flow occurs later after injection of regadenoson than suggested in the package insert (median 75 or average 102 seconds vs 20 seconds). Optimizing the timing of first-pass perfusion imaging may improve sensitivity in the detection of coronary stenoses.
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