Volume 13 Supplement 1
Local-look navigator gated and cardiac triggered echo-planar spectroscopic imaging of the heart
© Weiss et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
Single-voxel proton magnetic resonance spectroscopy has been shown to be a promising tool for assessing creatine  and myocardial triglycerides in humans [2, 3, 4]. A focus of interest is the correlation between triglyceride content in the myocardium and cardiac dysfunction . While spectral information from a single volume is sufficient when alterations with global effects on the heart are studied, a demand for higher and flexible spatial resolution exists when probing local changes. The objective of the current work was to implement a navigated local-look Echo-Planar Spectroscopic Imaging (EPSI) sequence for assessment of triglyceride and creatine content in the myocardium in vivo.
It has been demonstrated that local look navigator-gated and cardiac triggered spin echo EPSI can be used to assess distributions of myocardial triglyceride and creatine resonances during free-breathing acquisitions. Compared to single voxel techniques the EPSI method provides spectra from different regions of the myocardium. In future work higher B0 fields like 3T could be used to increase signal-to-noise ratios, to especially enhance the relatively weak signal of creatine.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.