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Impaired myocardial perfusion on CMR is associated with increased numbers of classical monocytes in STEMI patients treated by primary PCI

Introduction

Despite optimal revascularization strategies, STEMI patients often show impaired myocardial tissue reperfusion due to microvascular obstruction. Monocytes, especially the classical monocytes have been suggested to contribute to microvascular obstruction through a complex inflammatory response.

Purpose

To investigate the relation between the circulating number of classical monocytes and severity of myocardial perfusion impairment in patients with ST-elevated myocardial infarction (STEMI) treated with primary PCI.

Methods

Fifty-four patients underwent CMR first-pass perfusion imaging, late gadolinium enhancement (LGE) and functional imaging between 3-7 days after primary PCI.

Myocardial perfusion in the infarct core was evaluated semi-quantitatively from signal intensity versus time curves by calculation of the maximum upslope relative to a remote, normal segment. The number of classical (CD14++CD62L+) (CM) and nonclassical (CD14+CD62L-) monocytes (NCM) was measured by flow cytometry from a venous blood sample. Patients were divided in tertiles according to the monocyte count in the sample.

Results

Myocardial perfusion in the infarct core was significantly lower in patients with high numbers of CM (upper tertile) compared to low numbers (lower tertile) of CM (mean relative upslope in upper tertile 7.5 versus mid tertile 5.8 versus lower tertile 5.2, p=0.014). Also, patients with high numbers of CM had a larger infarct size (9.17 vs. 6.51 vs. 3.89 g/m2, p<0.001), more segments with microvascular obstruction at LGE (15.9 vs. 8.2 vs. 2.2% of segments, p=0.001), and greater impairment of ejection fraction (37.0 vs. 42.0 vs. 46.5%, p=0.001) than patients with low numbers of CM. No such relations were found for NCM. Figure 1.

Figure 1
figure1

* Significant difference in relative upslope value between lower and upper tertiles (p=0.014).

Conclusions

In reperfused STEMI patients, high numbers of classical monocytes are associated with impaired myocardial perfusion, increased myocardial injury and greater functional loss. This suggests a causal relationship between circulating monocytes after AMI and degree of myocardial damage in reperfused infarction.

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Correspondence to Lourens FHJ Robbers.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Robbers, L.F., van der Laan, A.M., Nijveldt, R. et al. Impaired myocardial perfusion on CMR is associated with increased numbers of classical monocytes in STEMI patients treated by primary PCI. J Cardiovasc Magn Reson 13, O93 (2011). https://doi.org/10.1186/1532-429X-13-S1-O93

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Keywords

  • Myocardial Perfusion
  • Late Gadolinium Enhancement
  • STEMI Patient
  • Lower Tertile
  • Microvascular Obstruction