- Oral presentation
- Open Access
CMR quantification of aortic regurgitation in asymptomatic patients with significant aortic regurgitation: prediction of clinical outcome
© Myerson et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
The timing of valve surgery in asymptomatic patients with significant aortic regurgitation can be challenging. Current indications focus on symptoms and left ventricular (LV) dilation/dysfunction, but prognosis is already reduced by this time. Quantification of the regurgitation has not previously been used to guide management, likely due to the difficulty of achieving this with echocardiography. Cardiovascular magnetic resonance (CMR) can accurately quantify aortic regurgitation and LV volumes, and we examined whether either could predict symptom development and the need for aortic valve surgery.
94 asymptomatic patients with moderate or severe aortic regurgitation on echocardiography were identified from four high volume CMR centres. CMR was performed to quantify aortic regurgitation and LV volume indices, and subsequent clinical follow up occurred for up to 7 years (mean 2.6 ±2.1 years). The best predictors of progression to symptoms and other conventional indications for surgery were determined.
CMR quantification of aortic regurgitation and LV volumes accurately predicts the progression to symptoms/surgery. Its use in patients with aortic regurgitation should be encouraged.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.