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Myocardial ASL perfusion reserve test detects ischemic segments in initial cohort of 10 patients with angiographic CAD
Journal of Cardiovascular Magnetic Resonance volume 13, Article number: P110 (2011)
This study sought to demonstrate the potential for myocardial arterial spin labeling (ASL) to identify the ischemic myocardial segments due to stenosis in coronary arteries as detected by X-ray angiography.
Myocardial ASL is a technique for the assessment of myocardial blood flow (MBF) without contrast agents. It can be safely applied to patients with end-stage renal disease who are not candidates for first-pass imaging with contrast agents. Myocardial ASL perfusion imaging performed at rest and during adenosine stress provides perfusion reserve (MBFstress/MBFrest), which is a common indicator for the severity of coronary artery disease. In healthy myocardium, perfusion reserve is known to be approximately four .
Twenty nine patients were recruited from those scheduled for routine cardiac MR (CMR) and X-ray angiography. Myocardial ASL measurements were obtained from a single mid short-axis slice at rest and during adenosine infusion (dosage: 0.14 mg/kg/min) on a GE Signa 3T scanner. The ASL sequence was composed of flow-sensitive alternating inversion recovery (FAIR) tagging and balanced steady-state free precession (SSFP) imaging . Perfusion reserve maps were generated in a standard short-axis view illustration by convolution with a Gaussian filter and resampling onto a polar coordinate .
Ten of the twenty-nine patients were found to have significant stenosis on X-ray angiography. Table 1 contains the most ischemic myocardial segments in these ten patients as identified by two cardiologists using either X-ray angiogram or ASL perfusion reserve map independently. Based on McNemar’s test with Bonferroni correction, there was no significant difference between X-ray and ASL MRI in identifying ischemia in all six myocardial segments (p = 1.0000, 0.6170, 0.4795, 0.1336, 0.4795, and 0.4795). Figure 1 contains perfusion reserve maps acquired using myocardial ASL in these patients. The average standard deviation of physiological noise was 0.22 ml/g/min at rest and 0.42 ml/g/min during stress .
There was visual agreement (except patients 7, 8, and 10) and no statistically significant difference between ischemic myocardial segments identified by ASL perfusion reserve maps and by X-ray angiograms. This suggests that myocardial ASL with vasodilation may have a potential to identify ischemic myocardial segments in patients with stenosis.
Kaufmann : Am J Physiol Heart Circ Physiol. 2007
Zun : MRM. 2009
Jao : US patent (pending)
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Zun, Z., Jao, T., Smith, N. et al. Myocardial ASL perfusion reserve test detects ischemic segments in initial cohort of 10 patients with angiographic CAD. J Cardiovasc Magn Reson 13, P110 (2011). https://doi.org/10.1186/1532-429X-13-S1-P110
- Myocardial Blood Flow
- Arterial Spin Label
- Adenosine Infusion
- Physiological Noise
- Ischemic Segment