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Myocardial feature tracking for viability assessment in ischemic cardiomyopathy
Journal of Cardiovascular Magnetic Resonance volume 13, Article number: P153 (2011)
To evaluate myocardial feature tracking (FT) as a potential novel quantitative analysis tool for the assessment of myocardial viability using LDDSMR.
Low dose dobutamine stress magnetic resonance imaging (LDDSMR) is a widely accepted technique for assessment of hibernating myocardium in patients with ischemic cardiomyopathy (ICMP). It is particularly helpful in patients with intermediate transmurality of scar where prediction of functional recovery by late gadolinium enhancement imaging (LGE) alone is difficult. Analysis of LDDSMR is usually based on visual assessment and is therefore considerably operator dependant. Recently myocardial feature tracking (FT) has been introduced. It tracks tissue voxel motion of cine-MR images to assess circumferential and radial myocardial strain independent of additional sequences.
15 consecutive patients with ICMP referred for viability assessment were studied at 3 Tesla (Philips Achieva) at rest and during LDDSMR. ICMP was defined as: angiographically established coronary artery disease, LV-EF ≤45% and ≥2 segments with wall motion abnormalities at rest. Myocardial function was studied by steady state free precession (SSFP) cine imaging in 3 short axis slices covering 16 myocardial segments, excluding the apex.
The same segments were studied with dedicated FT software (Diogenes MRI, Tomtec, Germany) to assess subendocardial and subepicardial circumferential (Ecc) and radial (Err) strain.
208 of 240 segments (87%) were analysed by two independent observers. 32 segments were excluded because of insufficient image quality or visualization of the outflow tract. Interobser-variability was: Ecc subendocardial r=0.84, Ecc subepicardial r=0.72 and Err r=0.7.
During LDDSMR (5 and 10 µg · kg-1· min-1) there was improvement in Ecc subendocardial, Ecc subepicardial (p<0.001, by repeated measures analysis) and Err (p=0.001, please refer also to Table 1). Normokinetic segments without scar (n=67) improved in Ecc subendocardial (p<0.001) and Ecc subepicardial (p=0.008) while Err remained unchanged with stress. Hypokinetic segments without scar (n=75) improved in all three strain values (Ecc subendocardial p=0.012 ; Ecc subepicardial p=0.035 ; Err p=0.001). Hypokinetic segments with non-transmural scar (n=60) showed improved Ecc subendocardial , Ecc subepicardial and Err up to 75% transmurality while transmurally scarred segments (n=6) remained unchanged with stress.
FT is a novel technique, which reliably detects quantitative wall motion derived from SSFP CINE imaging. It seems useful for quantitative analysis at rest and during low dose dobutamine stress for viability assessment in patients with ischemic cardiomyopathy.
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Schuster, A., Paul, M., Bettencourt, N. et al. Myocardial feature tracking for viability assessment in ischemic cardiomyopathy. J Cardiovasc Magn Reson 13, P153 (2011). https://doi.org/10.1186/1532-429X-13-S1-P153
- Late Gadolinium Enhancement
- Steady State Free Precession
- Ischemic Cardiomyopathy
- Feature Tracking
- Cine Imaging