Skip to main content

Global improvement in right ventricular function after Stage II Norwood operation in children with hypoplastic left heart assessed by serial MRI

Introduction

Hypoplastic left heart syndrome (HLHS) describes a spectrum of left heart hypoplasias, which leave the left ventricle unable to support the systemic circulation. Staged palliation consists of aortic reconstruction and systemic to pulmonary artery shunt in the neonatal period (stage I), followed at intervals by superior (Stage II) and then total cavopulmonary connection (Stage III). The initial operation results in a volume loaded systemic right ventricle (RV) which is reduced after Stage II. In our institution children are assessed prior to Stage II and Stage III with a cardiac magnetic resonance imaging (MRI) scan

Methods

Ethical and institutional approval was obtained. MRI scans of children with HLHS assessed prior to Stage II and Stage III surgery were analysed. RV volumes and function were assessed and indexed to body surface are (BSA). Currently ‘normal’ function is taken as an ejection fraction (EF) of >50%. Children were divided into two groups: those with RV EF >50% on the pre-Stage II MRI and those with RV EF <50% on this scan.

Results

51 patients had an analysable MRI scan before Stage II and before Stage III. 21 patients had an RV EF 50%. Demographics are shown in Table 1. The RV indexed end diastolic volume (iEDV) fell in both groups from the first to the second MRI, but more in those with an RV EF <50% (figure 1a). RV indexed end systolic volume (iESV) remained similar in both groups. RV indexed stroke volume (iSV) increased in the RV EF 50% group. RV EF increased by 22.8% in the RV EF 50% group (figure 1b). The greatest increase in RV EF was seen in the group with an RV EF <50% who had Stage II at less than 6 months of age (figure 1b).

Table 1 Table 1
Figure 1
figure1

Figure 1

Conclusions

Median RV EF of the group with an RV EF <50% at the time of the pre-Stage II MRI scan increased to the normal range by the pre-Stage III MRI scan. An increase was also seen in the >50% group. This suggests that the normal ranges may need to be adapted for operative stage, due to the RV loading after the Stage I surgery.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Hannah R Bellsham-Revell.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Bellsham-Revell, H.R., Razavi, R., Beerbaum, P. et al. Global improvement in right ventricular function after Stage II Norwood operation in children with hypoplastic left heart assessed by serial MRI. J Cardiovasc Magn Reson 13, P186 (2011). https://doi.org/10.1186/1532-429X-13-S1-P186

Download citation

Keywords

  • Magnetic Resonance Imaging
  • Cardiac Magnetic Resonance
  • Right Ventricle
  • Hypoplastic Left Heart Syndrome
  • Index Stroke Volume