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Dobutamine stress MRI catheterisation in patients with hypoplastic left heart syndrome after Fontan completion: preliminary results
© Bellsham-Revell et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
Exercise tolerance is often impaired in children with hypoplastic left heart syndrome(HLHS). It has been hypothesised this may be related to diastolic dysfunction of the single systemic right ventricle (RV), ventricular hypertrophy or to restricted pre-load from limited pulmonary venous return in Fontan physiology.
Children with HLHS referred for dobutamine stress MRI catheterisation were assessed with MRI volumetry and invasive pressure measurements at rest and at 10mcg/kg/min and 20mcg/kg/min of dobutamine. Results were normalised for body surface area and compared with normal adult left ventricle (LV) and RV1.
Dobutamine stress MRI in HLHS patients after Fontan completion appears to be safe and feasible, may provide insights into the physiology of the systemic RV at stress, and can potentially contribute to the understanding of decreased exercise tolerance in this group.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.