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  • Open Access

In-vivo right ventricular myocardial perfusion assessment using BOLD and first-pass cardiac magnetic resonance

  • 1,
  • 2,
  • 2 and
  • 3
Journal of Cardiovascular Magnetic Resonance201113 (Suppl 1) :P226

  • Published:


  • Cardiovascular Magnetic Resonance
  • Cardiac Magnetic Resonance
  • Right Ventricle
  • Blood Oxygen Level Dependent
  • Adenosine Stress


Evaluations of right ventricle (RV) parameters are feasible using echocardiographic, nuclear, computed tomography and cardiovascular magnetic resonance (CMR) techniques but perfusion of the RV is not routinely assessed. Knowledge of blood flow to myocardium of the RV might be a useful parameter in the assessment of disease states. Such a measurement might yield important information about congenital, ischemic, and acquired conditions of the right heart.


We sought to determine whether blood oxygen level dependent (BOLD) and first-pass (FP) CMR during adenosine are useful techniques to measure perfusion in myocardium of the RV.


Dogs (n=7) were prepared with a selective coronary artery catheter (Figure 1). Canines have left dominant circulation and the left circumflex supplies blood flow to the inferior RV myocardium. Thus, selective circumflex adenosine infusion in this model causes vasodilation of the inferior RV myocardial segment while blood from from the right coronary maintains normal blood flow in other areas. Animals were imaged on a 1.5-Tesla CMR scanner by BOLD and FP CMR before and after intracoronary adenosine (0.30 mg/min). Fluorescent microspheres were injected at rest and during adenosine stress through a left atrial catheter, implanted at the time of surgery. Image intensities of vasodilated and remote RV myocardium were measured. CMR perfusion indices were compared to relative perfusion of the RV based on fluorescent microsphere measurements.
Figure 1
Figure 1

Experimental model showing coronary catheter, sectioning, and right ventricular segmentation:


Changes in RV myocardial perfusion during adenosine were apparent in BOLD and FP CMR images (Figures 2, 3). Stress-rest CMR perfusion indices of the RV correlated with that determined by microspheres (y=0.11x + 0.96, R=0.77, and y=0.91x + 0.44, R=0.81, for BOLD and FP-CMR, respectively).
Figure 2
Figure 2

Example BOLD images of the RV (baseline shown at left, during adenosine shown at right) revealing increased image intensity (arrowheads) in the inferior segment during vasodilation:

Figure 3
Figure 3

Example FP images of the RV (precontrast at left, during gadolinium at right) revealing increased image intensity (arrowheads) in the inferior segment during pharmacologic vasodilation.


Data of the present study suggest that BOLD and FP CMR are useful techniques to assess of perfusion in the RV. To our knowledge, this is the first report of CMR to determine RV perfusion. In this animal model, BOLD and FP CMR during adenosine stress are non-invasive methods to assess RV myocardial perfusion.

Authors’ Affiliations

Heart South Cardiovascular, Alabaster, AL, USA
Northwestern University, Chicago, IL, USA
Cedars-Sinai Medical Center, Los Angeles, CA, USA


© Fieno et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.