Cardiac T2* measurements in patients with iron overload: a comparison of imaging parameters and analysis techniques
© Powell et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
In patients at risk for iron overload, measurement of myocardial T2* has emerged as an important non-invasive tool to detect preclinical evidence of toxic levels and titrate chelation therapy. Nevertheless, there exists some variation among practitioners in cardiac T2* calculation methods.
To examine the impact of different imaging parameters and data analysis techniques on the calculated cardiac R2* (1/T2*) in patients at risk for cardiac siderosis.
The study group consisted of 36 patients with thalassemia syndromes who had undergone clinical MRI assessment of cardiac siderosis using a standardized protocol and who were selected to yield a broad range of cardiac R2* values. Cardiac R2* measurements were performed on a 1.5 Tesla scanner using a ECG-gated, segmented, multiecho gradient echo sequence obtained in a single breath-hold. R2* was calculated from the signal intensity versus echo time data in the ventricular septum on a single mid-ventricular short-axis slice.
The addition of a blood suppression pre-pulse for cardiac R2* measurement yields similar R2* values, and improves reproducibility and interoberver agreement. The findings regarding other variations may be helpful in establishing a broadly accepted imaging and analysis technique for cardiac R2* calculation.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.