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Late Gadolinium Enhancement does occur in the Tako-Tsubo Cardiomyopathy - a quantitative cardiovascular magnetic resonance study
© Hamilton-Craig et al; licensee BioMed Central Ltd. 2011
- Published: 2 February 2011
- Cardiovascular Magnetic Resonance
- Cardiac Magnetic Resonance
- Late Gadolinium Enhancement
- Abnormal Wall Motion
- Myocardial Stunning
Tako-tsubo cardiomyopathy (TTC) accounts for 1% of admissions for chest pain in Japan and up to 1 in 30 cases referred for acute primary angioplasty in Western cohorts. The absence of myocardial late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) has been recommended in the literature to distinguish TTC from either acute myocardial infarction or myocarditis.
Data were retrospectively reviewed from 27 consecutive patients with confirmed Mayo Clinic criteria for TTC (clinical, ECG, angiographic and left ventriculographic findings) presenting to our institution over a 2 year period. A CMR (GE 1.5T Twinspeed) protocol of steady state free precession, triple inversion recovery, and myocardial LGE imaging was performed in the acute phase. LGE was quantified using standardized software (ReportCard V4.0), with both 2 and 5 standard deviations thresholds (SD) above normal remote myocardium, normalized to LV mass.
In this single-center series, LGE was present in 41% of cases of TTC, occurring in a diffuse pattern through the areas of myocardial stunning, 82% of which were >5SD above normal myocardium. This likely represents diffuse myocyte damage. Absence of LGE should not, therefore, be used as a diagnostic criterion for TTC. LGE does occur in the tako-tsubo cardiomyopathy, and presence of intense (>5SD) LGE appears associated with worse myocardial injury.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.