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Single breath-hold non-contrast thoracic mra using highly-accelerated parallel imaging with a 32-element coil array
Journal of Cardiovascular Magnetic Resonance volume 13, Article number: P374 (2011)
To evaluate the feasibility of performing non-contrast thoracic MRA with isotropic spatial resolution within a single breath-hold.
Contrast-enhanced 3D magnetic resonance angiography (CE-MRA) provides accurate diagnosis of aortic disease [1–4]. ECG-gated CE-MRA of the thoracic aorta is challenging, due to competing demands of high spatial resolution while imaging in a narrow window of the cardiac cycle within a breath-hold. In addition, nephrogenic systemic fibrosis in patients with impaired renal function is a concern with gadolinium-based contrast agents . Non-contrast ECG-gated MRA (NC-MRA) is a potential alternative , especially for patients with poor intravenous access or contraindications to gadolinium use. Navigator-gated NC-MRA can take approximately 10 minutes . We propose to perform breath-hold, ECG-gated NC-MRA (BH NC-MRA) using highly-accelerated parallel imaging with a 32-element coil array.
Following informed consent, 10 subjects (7 controls, 3 patients; 6 male, mean age=35.1 ±17.0 years) were imaged on a 1.5T scanner (Siemens, Avanto) with BH NC-MRA followed by CE-MRA. Imaging parameters for BH NC-MRA using balanced steady state free precession (b-SSFP) with T2 and fat-suppression preparation pulses were: TR/TE 2.3/1.6ms, FA70°, FOV 400x400x64mm, voxel size 1.6x1.6x1.6mm3, 2D GRAPPA acceleration of 3x2, segments 48, 6/8 partial Fourier in both phase encode and partition directions, partition oversampling 20%,mean scan time 19.4±4.1s. Both coil sensitivity (early systole) and MRA (mid diastole) data were acquired in the same breath hold (Figure 1). Pre- and post-contrast ECG-gated CE-MRA used similar parameters to achieve matched spatial resolution, TR/TE 3.6/1.1ms,,FA 17°,BW 330Hz/pixel,1D GRAPPA acceleration factor 2, mean scan time 39.4±10.5s. Gd-DTPA 0.15 mmol/kg at 2cc/sec was administered with arterial timing based on a timing bolus. Source and subtracted images (for CE-MRA) were reviewed in blinded fashion by a cardiologist and a radiologist. Image quality was scored (0-4; non-diagnostic to excellent) for 4 aortic segments (Table 1). Severity of artifacts was also evaluated (0-4; none to high).
This study demonstrates the feasibility of performing highly accelerated single BH NC-MRA with isotropic spatial resolution and diagnostic image quality. It has potential benefits of short scan time and repeatability without need for exogenous contrast, providing rapid, safe, entirely non-invasive assessment of the thoracic aorta
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Xu, J., Mcgorty, K., Lim, R. et al. Single breath-hold non-contrast thoracic mra using highly-accelerated parallel imaging with a 32-element coil array. J Cardiovasc Magn Reson 13, P374 (2011). https://doi.org/10.1186/1532-429X-13-S1-P374
- Thoracic Aorta
- Nephrogenic Systemic Fibrosis
- Aortic Disease
- Diagnostic Image Quality
- Quality Image Score