Dependence of scar contrast in LGE images on the time interval after contrast injection
© Vijayakumar et al; licensee BioMed Central Ltd. 2011
Published: 2 February 2011
To study the dependence of post-ablation scar visibility in late gadolinium enhancement (LGE) images of left arial wall on time interval after contrast agent injection
It was shown that LGE imaging can be used to evaluate post-ablation scar [1, 2] and pre-ablation remodeling of left atrium . Visibility of scar depends on a time interval between contrast agent injection and LGE scan. In this study, we try to determine, what time post contrast injection would give optimal contrast between post-ablation scar and blood (CNRSB) and scar and normal myocardium (CNRSM).
20-30 mins post contrast
30-40 mins post contrast
40-45 mins post contrast
Each group had 12 patients. Contrast to Noise Ratio (CNR) was computed as the ratio of the difference in signal intensity over a chosen region of interest in the scar and normal myocardium and the standard deviation of the noise observed in the blood pool. CNR was computed between scar and normal myocardium CNRSM & between scar and blood CRNSB.
CNR computed for each studied group
Time post contrast
CNRSM (mean ± std)
CRNSB (mean ± std)
25.2 ± 4 minutes
20.3 ± 9.1
8.7 ± 4.8
34.3 ± 2.5 minutes
20.2 ± 8.8
11.3 ± 5.9
42. ± 2.8 minutes
17.3 ± 3.5
10 ± 1.9
From these preliminary results, it follows that LGE imaging performed between 25 to 45 minutes post contrast injection give comparable visibility of post ablation scar.
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