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Reproducibility of strain and twist measurements calculated using CSPAMM tagging
Journal of Cardiovascular Magnetic Resonance volume 13, Article number: P52 (2011)
To establish inter-observer and inter-study variability of CSPAMM (complementary spatial modulation of magnetization) tagged CMR data.
The reproducibility of CSPAMM-derived myocardial strain and left ventricular twist have not been described in detail.
12 healthy volunteers (6 males, mean age 33±7 years) underwent CMR studies on a 1.5T system (Intera CV, Philips Healthcare, The Netherlands). Tagged CMR images were acquired at the apex, mid-ventricle and base with a CSPAMM pulse sequence (field of view: 300mm, matrix 128 x 128, slice thickness 10mm, tag separation 8mm, 18 phases, typical TR/TE 30ms/6ms, flip angle 25 degrees). In 6 volunteers repeat data sets were acquired after a mean interval of 8±3 days.
Data were analysed by two independent observers using Tagtrack software (Gyrotools, CH). Circumferential Langranian strain, radial Langranian strain and rotation were calculated for the three short axis slices. Endocardial and epicardial borders were drawn, and a midline calculated automatically. Left ventricular twist was calculated by subtracting the basal rotation from the apical rotation. The mean difference between paired measurements, the standard deviation (SD) of the differences and the coefficient of variability (Co-V) were calculated.
Circumferential strain increased from base to apex (Figure 1a). Mean (SD) difference in circumferential strain between the two operators was 6.9% (2.3), 8.2% (7.7) and 6.7% (5.0) at apex, mid-LV and base respectively. There was no significant difference in inter-observer variability in endocardial, midline and epicardial contours. See Table 1 for Co-V results.
Mean (SD) difference in mid-myocardium circumferential strain between visits was 6.7% (4.1), 6.5% (4.0) and 8.8 % (5.2) at apex, mid-LV and base respectively.
Mean (SD) difference in radial strain between operators was 28.1% (47.8), 17.6% (21.6) and 26.7% (25.6) and between visits was 7.3% (6.0), 21.3% (11.0) and 35.6% (29.6) at apex, mid-LV and base respectively.
The mean (SD) difference in mid-myocardium left ventricular twist between operators was 0.6o (0.3o) or 5.7% (4.3) and between visits was 1.2o (SD 0.9o) or 12.3% (9.9).
The inter-observer and inter-study variability of circumferential strain and LV twist measured from CSPAMM tagged CMR data are low, but are higher for radial strain.
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Swoboda, P., Larghat, A., Greenwood, J. et al. Reproducibility of strain and twist measurements calculated using CSPAMM tagging. J Cardiovasc Magn Reson 13 (Suppl 1), P52 (2011). https://doi.org/10.1186/1532-429X-13-S1-P52
- Circumferential Strain
- Radial Strain
- Short Axis Slice
- Myocardial Strain
- Basal Rotation