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Adenosine-induced stress myocardial perfusion MRI using SW-CG-HYPR with whole left ventricular coverage: comparison of results with X-ray angiography in patients with suspected CAD
Journal of Cardiovascular Magnetic Resonance volume 13, Article number: P78 (2011)
Introduction
Myocardial perfusion MRI with sliding-window conjugate-gradient HYPR (SW-CG-HYPR) allows increased spatial coverage (whole left ventricular coverage), resolution, signal-to-noise ratio and reduced motion artifacts. The accuracy of this technique for detecting coronary artery disease (CAD) has not been determined in a large number of patients.
Purpose
The purpose of this study was to prospectively evaluate the diagnostic performance of adenosine-induced stress myocardial perfusion MRI with SW-CG-HYPR in patients with suspected CAD.
Methods
Forty consecutive patients (23 men and 17 women; mean age, 56 ± 15 years) with suspected CAD who were scheduled for coronary angiography underwent myocardial adenosine stress perfusion MRI with SW-CG-HYPR at 3.0T. Perfusion defects were interpreted visually by 2 blinded observers and were correlated to x-ray angiographic stenoses ≥ 50%.
Results
The prevalence of CAD was 55%. In the per-patient analysis, the sensitivity, specificity and accuracy of SW-CG-HYPR myocardial perfusion imaging were 95%, 83% and 90%, respectively. In the per-vessel analysis, these values were 98%, 89% and 93%, respectively. Figure 1 illustrates the detection of significant CAD by SW-CG-HYPR myocardial perfusion imaging with correlation to X-ray coronary angiography.
A 56-year-old man with no prior cardiac history who presented with chest pain. (A) Myocardial perfusion MRI with sliding-window conjugate-gradient HYPR (SW-CG-HYPR) detects perfusion defects in the basal, mid, and apical lateral segments, corresponding to significant stenoses in the left circumflex coronary artery (LCX). (B) Coronary angiography (CA) confirms significant stenoses in the LCX.
Conclusions
Adenosine-Induced stress myocardial perfusion MRI using SW-CG-HYPR allows whole left ventricular coverage and has high diagnostic accuracy in patients with suspected CAD.
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Ma, H., Ge, L., An, J. et al. Adenosine-induced stress myocardial perfusion MRI using SW-CG-HYPR with whole left ventricular coverage: comparison of results with X-ray angiography in patients with suspected CAD. J Cardiovasc Magn Reson 13 (Suppl 1), P78 (2011). https://doi.org/10.1186/1532-429X-13-S1-P78
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DOI: https://doi.org/10.1186/1532-429X-13-S1-P78