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Adenosine-induced stress myocardial perfusion MRI using SW-CG-HYPR with whole left ventricular coverage: comparison of results with X-ray angiography in patients with suspected CAD
Journal of Cardiovascular Magnetic Resonance volume 13, Article number: P78 (2011)
Myocardial perfusion MRI with sliding-window conjugate-gradient HYPR (SW-CG-HYPR) allows increased spatial coverage (whole left ventricular coverage), resolution, signal-to-noise ratio and reduced motion artifacts. The accuracy of this technique for detecting coronary artery disease (CAD) has not been determined in a large number of patients.
The purpose of this study was to prospectively evaluate the diagnostic performance of adenosine-induced stress myocardial perfusion MRI with SW-CG-HYPR in patients with suspected CAD.
Forty consecutive patients (23 men and 17 women; mean age, 56 ± 15 years) with suspected CAD who were scheduled for coronary angiography underwent myocardial adenosine stress perfusion MRI with SW-CG-HYPR at 3.0T. Perfusion defects were interpreted visually by 2 blinded observers and were correlated to x-ray angiographic stenoses ≥ 50%.
The prevalence of CAD was 55%. In the per-patient analysis, the sensitivity, specificity and accuracy of SW-CG-HYPR myocardial perfusion imaging were 95%, 83% and 90%, respectively. In the per-vessel analysis, these values were 98%, 89% and 93%, respectively. Figure 1 illustrates the detection of significant CAD by SW-CG-HYPR myocardial perfusion imaging with correlation to X-ray coronary angiography.
Adenosine-Induced stress myocardial perfusion MRI using SW-CG-HYPR allows whole left ventricular coverage and has high diagnostic accuracy in patients with suspected CAD.
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Ma, H., Ge, L., An, J. et al. Adenosine-induced stress myocardial perfusion MRI using SW-CG-HYPR with whole left ventricular coverage: comparison of results with X-ray angiography in patients with suspected CAD. J Cardiovasc Magn Reson 13, P78 (2011). https://doi.org/10.1186/1532-429X-13-S1-P78
- Coronary Artery Disease
- Myocardial Perfusion
- Myocardial Perfusion Imaging
- Perfusion Defect
- Significant Coronary Artery Disease