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Myocardial T1 mapping in different cardiomyopathies at 3.0T
© Fernandes et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Cardiac Magnetic Resonance
- Dilate Cardiomyopathy
- Hypertrophic Cardiomyopathy
- Idiopathic Dilate Cardiomyopathy
Measure T1 times in patients with idiopathic dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), ischemic cardiomyopathy (ICM) and compare these values to normal controls using 3.0T CMR.
Diffuse myocardial fibrosis has been described in different cardiomyopathies and has recently been correlated to T1 times measured by cardiac magnetic resonance (CMR). Despite these advances it is yet unknown whether there are differences in T1 maps among these cardiomyopathies and if CMR can distinguish different levels of fibrosis in each category. Moreover, most work on T1 mapping has been carried on 1.5T scanners with limited data on these values at 3.0T.
T1 maps were measured pre and 10 minutes after the infusion of 0.2mmol/kg of gadolinium on 80 subjects (20 normal controls, 20 patients with ICM, 20 patients with DCM and 20 patients with HCM). Images were obtained in a mid-ventricular short axis plane using a Modified Look Locker Inversion Recovery (MOLLI) sequence. All images with different inversion times were transferred to an off-line workstation and analyzed by drawing a region of interest around the entire myocardium and fitting the data after heart rate correction. Infarct areas in patients with ICM were excluded. Values obtained pre and post contrast were compared using General Linear Model with post-hoc LSD.
Our results show that post contrast T1 mapping can distinguish different type of cardiomyopathies from controls at 3.0T. DCM and HCM show greatest reductions in T1 times suggesting increased diffuse fibrosis as compared to ICM.
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP).
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