Improved late gadolinium enhancement imaging of left ventricle with isotropic spatial resolution
© Akcakaya et al; licensee BioMed Central Ltd. 2012
Published: 1 February 2012
Recent studies have shown the prognostic value of the infarct border zone of late gadolinium enhancement (LGE) images in patients with myocardial infarction . This border zone has also been associated with ventricular arrhythmia [2, 3]. The accuracy of the characterization of this area depends on spatial resolution of the imaging. 3D LGE allows improved spatial resolution, especially in through-plane direction. However imaging with an isotropic spatial resolution necessitates very long scan time. In this study, we sought to investigate if compressed-sensing (CS) based image acceleration method  allows LGE imaging with isotropic spatial resolution.
A prospective random under-sampling LGE acquisition was implemented on 1.5T Philips scanner. A free-breathing ECG-triggered inversion-recovery GRE sequence with navigator-gating was used for all acquisitions on 18 patients (5 females, 52.8±16.3 years) 10 to 20 minutes after bolus infusion of contrast agent. Each subject were imaged using two LGE sequence in random order: a) a 3-fold-accelerated LGE scan with isotropic spatial resolution of 1.2-to-1.7 mm3, b) LGE scan with non-isotropic resolution of 1.7×1.7×4.0mm3 were performed with imaging parameters of TR/TE/α=5.2/2.6ms/25°, FOV=320×320×100mm3. Random undersampling was implemented as described in , where the central k-space (45×35 in ky-kz) was fully-sampled. Acquisition times were 3 mins assuming 100% scan efficiency at 70 bpm for both scans. The images from the accelerated scans were reconstructed using an advanced CS-technique, called LOST .
Accelerated LGE imaging with isotropic spatial resolution allows improved visualization of scar morphology. Further quantitative measurements of infarct border zones in a larger cohort of patients are needed to better understand the prognostic value of the improved scar imaging.
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