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Cardiac magnetic resonance myocardial feature tracking correlates with natural radial strain and corresponds to inotropic stimulation

Summary

We have demonstrated that cardiac magnetic resonance (CMR) myocardial feature tracking (FT) and natural radial strain correlate and correspond to inotropic stimulation. CMR-FT has the potential for quantitative wall motion assessment at rest and during dobutamine stress magnetic resonance (DSMR) imaging.

Background

CMR-FT is a recently introduced technique for tissue voxel motion tracking on standard steady-state free precession (SSFP) images to derive radial myocardial mechanics. CMR-FT has the potential to facilitate DSMR analysis however has not yet been compared to external reference standards (with stress) such as SSFP derived natural radial strain.

Methods

10 healthy subjects were studied at 1.5 Tesla. LV short-axis radial strain ErrSAX was derived from SSFP cine images using dedicated CMR-FT software (Diogenes MRI prototype, Tomtec, Germany) at rest and during dobutamine stress (10 and 20 μg * kg-1* min-1). Natural radial strain values (loge [End-systolic wall thickness/end-diastolic wall thickness]) were calculated in identical segments as analysed for ErrSAX using commercially available software (Philips View Forum, The Netherlands). 95% confidence intervals (CI) of the difference and p-values were calculated to compare the 2 techniques.

Results

In all volunteers strain parameters could be derived from the SSFP images at rest and stress. ErrSAX values showed significantly increased contraction with DSMR (rest: 19.6±14.6; 10 μg: 31.8±20.9; 20 μg: 42.4±25.5, p<0.05). Natural radial strain values increased with dobutamine (rest: 24±8.9; 10 μg: 36.5±8.9; 20 μg: 44.2±8.5, p<0.05).

There was reasonable agreement between mean ErrSAX and natural radial strain at rest and with dobutamine stress (figure 1 and table 1) as determined by 95% CI of the difference.

Figure 1
figure1

Bland Altman Plots showing the relationship between ErrSAX and natural radial strain. ErrSAX = left ventricular short-axis radial strain.

Table 1 Table 1

Conclusions

CMR-FT correlates with natural radial strain derived from SSFP cine imaging. Both measures correspond to inotropic stimulation. CMR-FT holds promise of easy and fast quantification of wall mechanics and strain.

Funding

AS receives grant support from the British Heart Foundation (BHF) (RE/08/003 and FS/10/029/28253) and the Biomedical Research Centre (BRC-CTF 196). SK receives grant support from the American College of Cardiology Foundation, the Edna Ittner Pediatric Foundation, and the Children’s Hospital and Medical Center Foundation.

Author information

Correspondence to Andreas Schuster.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schuster, A., Kutty, S., Padiyath, A. et al. Cardiac magnetic resonance myocardial feature tracking correlates with natural radial strain and corresponds to inotropic stimulation. J Cardiovasc Magn Reson 14, O50 (2012). https://doi.org/10.1186/1532-429X-14-S1-O50

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Keywords

  • Cardiac Magnetic Resonance
  • Dobutamine
  • Dobutamine Stress
  • Feature Tracking
  • British Heart Foundation