- Oral presentation
- Open Access
Detecting acute reperfusion myocardial hemorrhage with CMR: a translational study
© Kali et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Image Resolution
- Translational Study
- Late Enhancement
- Noninvasive Detection
- Monoexponential Decay
Hemorrhage is a frequent hallmark of large acute reperfused myocardial infarctions (rMI). Recently, there has been a growing interest in CMR for noninvasive detection of hemorrhage in rMI. While T2*- and T2-weighted CMR have been used for this purpose, there is a lack of consensus on which of these methods is the most appropriate and reliable. We investigated the relative abilities of T2 and T2* CMR for detecting hemorrhage in rMI in a canine model and patients.
Canines (n=14), subjected to ischemia-reperfusion (I/R) injury (3 hrs of LAD occlusion followed by reperfusion), underwent CMR (1.5T) studies on day 5 post reperfusion. T2*-weighted (multi GRE; TE=3.4-18.4ms (6 echoes)), T2-weighted (T2-prep SSFP; prep times=0, 24 and 55 ms), T2-STIR (TE=64 ms) and Late Enhancement (LE) images covering the LV were acquired. Imaging resolution of all the scans was 1.3x1.3x8 mm3.
Patients (n=14) underwent CMR (1.5T) on day 3 post angioplasty for STEMI after providing informed consent. T2*-weighted (TE=2.6-13.8ms (6 echoes)), T2-STIR (TE=61ms) and LE images covering the LV were acquired. Imaging resolution of all the scans was 1.4x1.4x10 mm3.
T2* and T2 maps were constructed by fitting the multi-echo data to monoexponential decay. A threshold-based signal analysis was used to identify hemorrhagic (Hemo+) and non-hemorrhagic (Hemo-) infarcts. T2-STIR signal intensity (STIR-SI), T2* and T2 values, measured from Remote, Hemo- and Hemo+ regions, were compared. Statistical significance was set at p<0.05.
Representative T2* map, T2-STIR and LE images, acquired from a patient (day 3 post angioplasty) are shown in Figure 2. Consistent with the animal studies, mean T2* of Hemo+ was lower than the mean T2* of both Remote and Hemo- (-46%, p<0.001; Fig.2), while no differences were observed between T2* of Remote and Hemo- (p=0.61). Mean STIR-SI of both Hemo- and Hemo+ were greater than that of Remote (78% and 33% respectively; p<0.001), with the mean STIR-SI of Hemo- greater than that of Hemo+ (p<0.001).
This work was supported in part by grants from American Heart Association (SDG 0735099N) and National Heart, Lung, And Blood Institute (HL091989).
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