- Oral presentation
- Open Access
Cine-ASL: a new arterial spin labeling method for myocardial perfusion mapping in mice using a Cine-FLASH labeling and readout module
© Troalen et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Myocardial Perfusion
- Myocardial Blood Flow
- Arterial Spin Label
- Arterial Input Function
- Isoflurane Concentration
This study presents a novel arterial spin labeling method to assess myocardial perfusion in small rodents. An ECG-gated pseudo-continuous labeling approach is combined with simultaneous readout over the cardiac cycle using Cine-FLASH. This method allows shorter acquisition times than the previously used Look-Locker FAIR gradient-echo technique while preserving spatial resolution and robustness with respect to cardiac motion. Perfusion measurements were carried out on five mice with both techniques under different anesthetic conditions. Perfusion maps and values show good accordance between both experiments.
Arterial spin labeling (ASL) has been developed and used to quantitatively map rodent myocardial blood flow (MBF) for more than a decade. There is growing interest in improving sensitivity and measurement strategy, because accurate and motion-robust acquisitions are still time-consuming with typical measurement times of about 20 minutes. Here, we propose to combine continuous Cine-MRI gradient echo readout with a pseudo-continuous arterial labeling approach, which leads to a perfusion-dependent stationary regime.
We present a non-invasive and accurate MRI method to quantify MBF in vivo in mice using a new labeling and readout approach. The steady-state Cine-FLASH readout module allows for averaging of the steady perfusion-dependent magnetization difference over several cardiac cycles and can be used to improve sensitivity.
CNRS, UMR 6612.
Agence Nationale de la Recherche -08-BLANC-0058-01.
Ph.D. Grant Siemens France (TT).
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.