Application of a high resolution T1 mapping with MOLLI (hrMOLLI) in patients in clinical setting: a reproducibility study
© Pastor et al; licensee BioMed Central Ltd. 2012
Published: 1 February 2012
Several methodologies were proposed to evaluate myocardial T1 values by cardiovascular magnetic resonance based on Gadolinium contrast enhancement. Whereas potentially valuable for evaluation of myocardial fibrosis, none of these methodologies have been sufficiently robust and consistently translated into clinical routine. We propose that imaging with a high-resolution modified Look-Locker inversion recovery sequence (hrMOLLI) of native and post-contrast myocardium can provide a robust tool in the clinical setting.
Myocardial fibrosis is associated with myocardial dysfunction and remodelling leading to adverse outcomes. We propose that imaging with a high-resolution modified Look-Locker inversion recovery sequence (hrMOLLI) of native and post-contrast myocardium can provide a robust tool in the clinical setting.
T1 maps could be analysed in 94% of all images obtained. Intra-observer mean differences (MD) for T1 values were 1.3ms (95%CI:-12.4-15.4) for native scans and 0.7 ms (-7.9-12.3) for overall postcontrast scans, whereas interobserver MDs were 0.3 ms (-6.3 -5.3) and 0.1 (-3.4 to 4.2), respectively. We further demonstrate an excellent overall (pre- and postcontrast) intra-and interobserver agreement in T1 relaxation times (intraobserver: r= 0.94, p<0.0001; interobserver: R=0.91, p<0.0001). When assessed separately the postcontrast data showed better agreement within and between observers, respectively (r~0.94, p<0.0001 for both) than in the precontrast native scans (intraobserver r= 0.81, p <0.0001; interobserver r=0.79, p<0.001). We further revealed close agreements between repeated studies (r=0.91, p<0.001; MD: 2.4 msec (95%CI: -3.1-10.2).
We demonstrate that imaging with hrMOLLI as a single breath-held scan pre and postcontrast administration provides a robust tool to reproducibly derive T1 relaxation times in clinical setting.
NIHR British Research Centre.
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