- Oral presentation
- Open Access
Quantitative T1 mapping and the fibrotic index in normal healthy volunteers; relationship to aging and cardiac dimensions
© Neilan et al; licensee BioMed Central Ltd. 2012
- Published: 1 February 2012
- Cardiac Magnetic Resonance
- Myocardial Fibrosis
- Short Axis Slice
- Normal Healthy Volunteer
- Diffuse Myocardial Fibrosis
We aimed to publish normal data for the fibrotic index in a group of healthy volunteers. In healthy volunteers, the fibrotic index has acceptable test characteristics, has a range from 0.23 to 0.33, and is associated with age, LA volume and LV mass.
Current cardiac magnetic resonance (CMR) techniques provide an accurate assessment of replacement myocardial fibrosis (MF), but are of limited value for the detection and quantification of diffuse MF. T1 mapping is a novel approach for quantification of the expansion of the extracellular matrix. However, there are little published data on the normal range of the FI and its variation with age and gender.
Twenty seven healthy volunteers underwent a standard CMR with administration of gadolinium (Gd). T1 measurements, extending to 30 minutes post-contrast, were performed with a segmented, breath-hold Look-Locker sequence in 3 short axis slices, using 100 ms, and 50 ms for temporal resolution of one pre- and three post-contrast acquisitions, respectively. We tested the segmental, inter-slice, inter-, intra-, and test-retest characteristics of the fibrotic index, as well as the association with other cohort characteristics.
In healthy volunteers, the fibrotic index has acceptable test characteristics, has a range from 0.23 to 0.33, and is associated with age, LA volume and LV mass.
Dr. Neilan is supported by an NIH T32 Training Grant (T32HL09430101A1).
Dr. Kwong receives salary support from a research grant from the National Institutes of Health (R01HL091157).
Dr. Jerosch-Herold is supported in part by a research grant from the National Institutes of Health (R01HL090634-01A1).
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.